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Advanced genetics course : genetic analysis trends and concepts : course manual [Lecture notes]
Slakhorst, M. \ Belt, J. van de \ Bastiaans, E. \ Jong, H. de \ Pannebakker, B. \ Visser, A. de \ Debets, F. \ Koomen, J. \ Wijnen, c. \ Neijenhuis, R. \ Grum Grzhimaylo, A. \ Zhang, J. \ Botet Vaca, R. \ Vreeburg, S. \ Wijnen, C. \ Bukovinszkine Kiss, G. \ Peppel, L. van de \ Groeneboom, A. \ Zandveld, J. \ 2015
genetics - genetic variation - mutations - recombination

Used in course: GEN-30306 Genetic Analysis, Tools and Concepts (GATC)
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Elements of evolutionary genetics [Monograph]
Charlesworth, B. \ Charlesworth, D. \ cop. 2010
genetics - evolution - genetic diversity - population genetics - molecular genetics - genomes - natural selection - mutations - life history - textbooks - evolutionary genetics

This textbook shows readers how models of the genetic processes involved in evolution are made (including natural selection, migration, mutation, and genetic drift in finite populations), and how the models are used to interpret classical and molecular genetic data. The topics covered include genetic variation, DNA sequence variability and its measurement, the different types of natural selection and their effects (e.g. the maintenance of variation, directional selection, and adaptation), the interactions between selection and mutation or migration, the description and analysis of variation at multiple sites in the genome, genetic drift, and the effects of spatial structure. The final two chapters demonstrate how the theory illuminates our understanding of the evolution of breeding systems, sex ratios and life histories, and some aspects of genome evolution.


Used in course: GEN-30806 Population and Quantitative Genetics
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Evolution: an introduction [Monograph] - 2nd edCompanion website
Stearns, S.C. \ Hoekstra, R.F. \ 2005
evolution - coevolution - phylogeny - speciation - genetic variation

The second edition of Evolution introduces the basic mechanisms of microevolution, natural selection, and macroevolutionary processes such as speciation and extinction. It also examines key events in evolution throughout the geological record and discusses coevolution and evolutionary medicine. In addition, the text discusses unsolved problems and looks ahead to future developments in this dynamic field. The text is organized into five parts. Part One introduces the basic mechanisms of microevolution: selection, inheritance, and development. Part Two considers how natural selection has designed organisms for reproductive success. Part Three explores macroevolutionary processes such as speciation and extinction. Part Four examines key events in evolution throughout the geological record. Part Five discusses coevolution and evolutionary medicine, which integrate and contrast micro- and macroevolution. The book closes with a chapter that recapsulates major issues, discusses unsolved problems, and looks ahead to future developments in this dynamic field.


Used in course: GEN-11306 Evolution and Systematics; NEM-20806 Basics of Infectious Diseases
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Fundamental molecular biology [Monograph] - 2nd edCompanion website
Allison, L.A. \ cop. 2012
molecular biology - dna - rna - transcription - replication - gene regulation - gene expression - genetically engineered organisms - genomics - textbooks

This textbook provides a distillation of the essential concepts of molecular biology, and is supported by current examples, experimental evidence, an outstanding art program, multimedia support and a solid pedagogical framework. It has a solid coverage of traditional topics, and a broad coverage of RNA structure and function, epigenetics and medical molecular biology.


Used in course: MOB-20306 Gene Technology; GEN-11806 Fundamentals of Genetics and Molecular Biology
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Fundamentals of genetics and molecular biology [Lecture notes] - Period 3, 2016-2017
Eck, Herman van \ Debets, Fons \ Franssen, henk \ Madsen, Ole \ Schoustra, Sijmen \ 2016

Used in course: GEN-11806 Fundamentals of Genetics and Molecular Biology
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Genetic Analysis Trends and Concepts GATC : manual practicals [Lecture notes]
Slakhorst, M. \ Visser, A. de \ Debets, F. \ 2012
genetics - genetic analysis

Used in course: GEN-30306 Genetic Analysis, Tools and Concepts (GATC)
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Introduction to genetic analyis [Lecture notes] - Period 1, 2016-2017
Pannebakker, Bart \ Keurentjes, Joost \ Debets, Fons \ 2016

Used in course: GEN-21306 Introduction to Genetic Analysis
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Introduction to genetic analysis [Monograph] - Eleventh edition
Griffiths, A.J.F. \ Wessler, S.R. \ Carroll, S.B. \ Doebley, J. \ [2015]
genetics - genetic analysis - genes - gene expression - inheritance - evolution - genomes - genomics - population genetics - textbooks

Used in course: BIC-10306 Practical Biological Chemistry; GEN-11806 Fundamentals of Genetics and Molecular Biology; GEN-30306 Genetic Analysis, Tools and Concepts (GATC); GEN-20306 Molecular and Evolutionary Ecology; GEN-21306 Introduction to Genetic Analysis
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Manual plant biotechnology practical [Lecture notes]
Keurentjes, J. \ Aarts, M. \ Bouwmeester, H. \ Gremmen, B. \ Schaart, J. \ Joosten, M. \ Schots, A. \ Hanhart, C. \ Raaij, D. van \ Westerhof, L. \ [2013]
plant biotechnology - genetic engineering - gene transfer - bioinformatics - gene isolation - gene expression

Used in course: GEN-20806 Plant Biotechnology
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Molecular and evolutionary ecology [Lecture notes] - 14th ed
Wageningen University \ 2015
molecular biology - molecular genetics - biological techniques - ecology - evolution - polymerase chain reaction - genetics

Used in course: GEN-20306 Molecular and Evolutionary Ecology
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Molecular markers, natural history, and evolution [Monograph] - 2nd ed
Avise, J.C. \ 2004
genetic markers - biochemical markers - evolution - molecular biology - phylogeny - origin - natural history

This treatment of molecular natural history and evolution addresses the many biological applications for molecular genetic markers from the perspectives of population biology, natural history, and organismal phylogeny.


Used in course: GEN-20306 Molecular and Evolutionary Ecology
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Plant biotechnology : the genetic manipulation of plants [Monograph] - 2nd ed
Slater, A. \ Scott, N.W. \ Fowler, M.R. \ 2008
transgenic plants - genomes - gene expression - genetic transformation - tissue culture - genetic engineering - disease resistance - pest resistance - genetic vectors - herbicide resistance - techniques

This book presents a balanced exploration of the technology behind genetic manipulation, and the application of this technology to the growth and cultivation of plants. The book describes the techniques underpinning genetic manipulation and thereby makes use of case studies to illustrate how this influential tool is used in practice.


Used in course: GEN-20806 Plant Biotechnology; PBR-23803 Plant Biotechnology (DL)
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Population & quantitative genetics [Lecture notes] - Edition 2016-2017, period 6
Aanen, Duur \ Bijma, Piter \ Hooft, Pim van \ Zwaan, Bas \ 2017

Used in course: GEN-30806 Population and Quantitative Genetics
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Practicals manual 2010 plant biotechnology [Lecture notes]
Aarts, M. \ 2010
genetic transformation - textbooks - plant biotechnology - protocols

Used in course: GEN-20806 Plant Biotechnology
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Principles of population genetics [Monograph] - 4th ed
Hartl, D.L. \ Clark, A.G. \ 2007
population genetics - quantitative genetics - genetic variation - phenotypes - selection - evolution - textbooks

Fourth Edition is a thoroughly updated introduction to the field that is at last ascending to its rightful position of centrality to evolutionary genomics and human genetics. Rapid and inexpensive genotyping and sequencing have produced a profusion of data on genetic variation, along with a pressing need to inform students from many fields about the models that describe the underlying processes that give rise to observed patterns of genetic variation. This book provides a balanced presentation of theory and observation for students at the undergraduate and graduate levels as well as newcomers from fields like human genetics. The logical development of the models of population genetics encourages a deeper understanding of the principles, and the text has been rewritten with the goal to optimize its use as a teaching aid. It introduces the principles of genetics and statistics that are relevant to population studies, and examines the forces affecting genetic variation from the molecular to the organismic level. Integrated throughout the book are descriptions of molecular methods used to study variation in natural populations, as well as explanations of the relevant estimation theory using actual data. Chapter 1 presents the fundamental observations and means for quantifying amounts and structure of genetic variation in natural populations. Chapter 2 gives a detailed examination of the implications of random mating for one locus and multiple loci and establishes the basic principles for thinking about mathematical models of variation. Chapter 3 presents the classic Wright-Fisher model as well as the coalescent approaches to random genetic drift. Chapter 4 adds mutation to models of drift and lays down the foundations for the neutral theory of molecular evolution. Natural selection in its many guises gets a thorough coverage in Chapter 5. Chapter 6 examines population subdivision and its consequences for the distribution of genetic variation among subpopulations, including the hierarchical F statistics used in estimating these effects. Molecular population genetics, including applications of coalescent theory, is the subject of Chapter 7. Evolutionary quantitative genetics is covered in Chapter 8, including an up-to-date treatment of the use of molecular markers for mapping and assisting in selection of quantitative characters. Chapter 9 is a new addition and covers the exciting field of population genomics, or the analysis of population genetic principles at a genome-wide scale. Finally, because of the explosion in genome-wide polymorphism data in humans and the realization that many problems in empirical population genetics need to be tuned to special, non-equilibrium circumstances of human populations, the authors devote Chapter 10 to human population genetics. Applications of principles discussed in the text are illustrated with numerous examples of worked problems, using actual data. Many vital Web links are scattered throughout the text to connect the material to up-to-the-minute progress in this exciting field. Each chapter ends with a complete summary and offers several problems for solution, to reinforce and further develop the concepts.


Used in course: GEN-30806 Population and Quantitative Genetics
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A primer of human genetics [Monograph]
Gibson, Greg \ 2015
Human genetics - Medical genetics

A Primer of Human Genetics is an introductory textbook designed to give students the foundation they need to understand and appreciate the extraordinary shifts in human genetics that have accompanied the arrival of genomics. The book lays out the key concepts of human evolution, quantitative genetics, and personalized medicine before describing the tools that are missing from most contemporary textbooks: genome-wide association studies, whole-genome resequencing, gene expression and epigenome profiling, and integrative genomics. The final section provides an up-to-date survey of specific findings in six major domains of human disease: immunological, metabolic, cardiovascular, cancer, neuropsychological, and aging disorders. After reading this textbook, not only will students be better equipped to read current literature, they will gain a sense of the impact that the revolution in genomics has had for our understanding of the human condition, as well as of the major trends in human genetics research. Students are assumed to have a core understanding of genetics such as would be obtained in a general genetics class. Each chapter is approximately 20 pages long, and organized under up to ten sub-headings, most of which incorporate an illustrative figure. Chapter summary points recap the key messages, and references point students to key reviews and contemporary highlights. Several of the chapters contain a single box, which provides extra material on topics such as "Consent and Responsible Conduct of Research" and "Methylation Analysis in Biology."--Publisher description.


Used in course: GEN-21306 Introduction to Genetic Analysis
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A primer of population genetics [Monograph] - 3rd ed
Hartl, D.L. \ 2000
population genetics

The use of molecular methods to study genetic polymorphisms has made a familiarity with population genetics essential for any biologist whose work is at the population level.This third edition, provides a concise but comprehensive introduction to population genetics. The four chapters of the book address genetic variation, the causes of evolution, molecular population genetics and the genetic architecture of complex traits. Chapter-end problems reinforce ideas and, while there are some equations, the emphasis is on explanation rather than derivation.


Used in course: GEN-30806 Population and Quantitative Genetics
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