Record nummer 1808223
Titel artikel Alternative approaches can greatly reduce the number of fish used for acute toxicity testing
Auteur(s) Hoekzema, C.C. ; Murk, A.J. ; Waart, B.J. van de
Tijdschrifttitel Environmental toxicology and chemistry : an international journal : a monthly publication of the Society of Environmental Toxicology and Chemistry
Deel(Jaar)Nummer 25(2006)5
Paginering 1322 - 1325
Annotatie(s) 19 refs
Online full text
Trefwoorden (cab) toxiciteit / chemicaliën / tests / toxicologie / testen / vissen
Rubrieken Milieutoxicologie, ecotoxicologie
Publicatie type Artikel
Taal Engels
Toelichting (Engels) Acute toxicity tests with algae, daphnids, and fish are required for the classification and environmental risk assessment of chemicals. The degree of risk is determined by the lowest of these acute toxicity values. Many ecotoxicological programs are seeking to reduce the numbers of fish used in acute toxicity testing. The acute threshold test is a recently proposed strategy that uses, on average, only 10 (instead of 54) fish per chemical. We examined the consequences of reducing the number of fish used in toxicity testing on the ultimate outcome of risk assessments. We evaluated toxicity data sets for 507 compounds, including agrochemicals, industrial chemicals, and pharmaceuticals from our internal database
Betrokken instanties WUR, Sectie Toxicologie
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