Record nummer 2019106
Titel artikel In vitro characterization of the effectiveness of enhanced sewage treatment processes to eliminate endocrine activity of hospital effluents
Auteur(s) Maletz, S. ; Floehr, T. ; Beier, S. ; Klümper, C. ; Brouwer, A. ; Behnisch, P. ; Higley, E. ; Giesy, J.P. ; Hecker, M. ; Gebhardt, W. ; Linnemann, V. ; Pinnekamp, J. ; Hollert, H.
Tijdschrifttitel Water research : the journal of the International Association on Water Quality
Deel(Jaar)Nummer 47(2013)4
Paginering 1545 - 1557
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Trefwoorden (cab) afvalwaterbehandeling / ziekenhuisafval / geneesmiddelenresiduen / synthetische oestrogenen / aquatische ecologie / bioreactoren / membranen / ozon / watercontact / luciferasen / steroïdogenese / in vitro
Rubrieken Afvalwaterbehandeling
Publicatie type Artikel
Taal Engels
Toelichting (Engels) The present study was part of a proof of concept study at a medium sized country hospital in western Germany that investigated efficiency of advanced treatment processes to remove toxic potencies from sewage. The objective of this study was to determine efficiency of a membrane bioreactor with subsequent ozonation to remove endocrine-active chemicals from hospital effluents. Endocrine activities were assessed by use of three in vitro bioassays: 2 receptor-mediated, transactivation assays, the Lyticase Yeast Estrogen Screen (LYES) and Estrogen Receptor mediated Chemical Activated LUciferase gene eXpression (ER CALUX®) assay, and the H295R Steroidogenesis Assay (H295R) that detects effects on the steroid synthesis pathway. The results obtained as part of this study demonstrated applicability of in vitro assays for monitoring of endocrine-modulating potency of treated sewage.
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