Record nummer 2245848
Titel artikel Detection of Multiple Hormonal Activities in Wastewater Effluents and Surface Water, Using a Panel of Steroid Receptor CALUX Bioassays
Auteur(s) Linden, S.C. van der ; Heringa, M.B. ; Man, H. ; Sonneveld, E. ; Puijker, L.M. ; Brouwer, A. ; Burg, B. van der
Tijdschrifttitel Environmental science & technology / American Chemical Society
Deel(Jaar)Nummer 42(2008)15
Paginering 5814 - 5820
Online full text
Publicatie type Artikel
Taal Engels
Toelichting (Engels) It is generally known that there are compounds present in the aquatic environment that can disturb endocrine processes, for example via interaction with the endogenous hormone receptors. Most research so far has focused on compounds that bind to the estrogen and/or androgen receptor, but ligands for other hormone receptors might also be present. In this study, a newly completed panel of human cell derived CALUX reporter gene bioassays was utilized to test water extracts for estrogen (ER), as well as androgen (AR), progesterone (PR), and glucocorticoid (GR) receptor mediated transactivation activity. Effluents from industry, hospital, and municipal sewage treatment plants, as well as tap water and different sources of surface water were tested.
Betrokken instanties KWR, Watercycle Research Institute
Vrije Universiteit Amsterdam
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