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Record number 2237765
Title Acanthamoeba keratitis : diagnosis and treatment
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Xuguang Sun
Author(s) Sun, Xuguang
Publisher Singapore : Springer
Publication year 2018
Description 1 online resource (xv, 116 pages) illustrations (some color)
Notes Includes bibliographical referencesshow all notes
Intro
Preface
Acknowledgments
Contents
About the Authors
1: Epidemiology
1.1 Incidence in Developed Countries and Regions
1.2 Incidence in Developing Countries and Regions
References
2: Etiology
2.1 Biological Characteristics of Free-Living Amoeba
2.2 Acanthamoeba spp
2.2.1 Trophozoite
2.2.2 Cyst
2.2.3 Classification of Acanthamoeba
2.2.4 Genotyping Identification of Acanthamoeba Strains in the Natural Environment
2.3 Naegleria spp
2.3.1 Trophozoite
2.3.2 Cyst
References
3: Pathological Mechanisms and Immunological Reactions
3.1 Pathological Mechanisms3.1.1 Adhesive Attraction to the Corneal Epithelium
3.1.2 Non-contact Cytolysis Induced by Protease
3.1.3 Contact-Dependent Cytolysis
3.1.4 Apoptosis Mediated by Acanthamoeba
3.1.5 Cytokines
3.2 Immunological Reactions
3.2.1 Non-specific Immunoreaction
3.2.2 Specific Immunoreaction
3.2.2.1 Antigen-Presenting Cell
3.2.2.2 Humoral Immunity
3.2.2.3 Cellular Immunity
3.2.3 Preventive Immunoreaction
References
4: Clinical Manifestations
4.1 General Conditions
4.1.1 Distribution Characteristics of Ages
4.1.2 Distribution Characteristics of Genders4.1.3 Distribution Characteristics of Occupations
4.1.4 Risk Factors
4.1.5 Seasonal Morbidity
4.2 Clinical Symptoms
4.3 Clinical Signs
4.3.1 Early Stage
4.3.2 Advanced Stage
4.3.3 Late Stage
4.4 Coinfection
4.5 Complications
4.5.1 Anterior Uveitis
4.5.2 Intraocular Hypertension or Secondary Glaucoma
4.5.3 Anterior Scleritis
4.5.4 Complicated Cataract
References
5: Diagnosis and Differential Diagnosis
5.1 Diagnosis of Acanthamoeba Keratitis
5.1.1 Clinical Diagnosis
5.1.2 Etiological Diagnosis
5.2 Differential Diagnosis of Acanthamoeba Keratitis5.2.1 Key Points for Differential Diagnosis of Acanthamoeba Keratitis from Viral Keratitis
5.2.2 Key Points of Differential Diagnosis of Acanthamoeba Keratitis from Fungal Keratitis
5.2.3 Key Points of Differential Diagnosis of Acanthamoeba Keratitis from Bacterial Keratitis
References
6: Laboratory Examination
6.1 Method of the Cornea Sample Collection
6.1.1 Sample Collection for the Cornea Smear Cytology Examination
6.1.2 Sample Collection for the Culture of Acanthamoeba
6.2 Conventional Methods of Examination
6.2.1 Smear Cytological Examination of the Corneal Scraping6.2.2 Cultivation of Acanthamoeba
6.2.3 Test of In Vitro Susceptibility to Acanthamoeba
6.2.4 Histopathological Examination
6.2.5 Flagellation Test
6.3 Special Examination Methods
6.3.1 Special Staining Methods
6.3.1.1 Iodine Tincture Stain
6.3.1.2 Lactophenol Cotton Blue Stain
6.3.1.3 Fuchsin Stain
6.3.1.4 Calcofluor White Staining
6.3.1.5 Acridine Orange Staining
6.3.2 Electron Microscope Examination
6.3.3 Molecular Biology Examination
References
7: Treatment of Acanthamoeba Keratitis
ISBN 9789811052125; 9811052123
Online Get the document, find related information or use other SFX services
Keyword(s) Acanthamoeba / Keratitis
Publication type Monograph
Language English
About This book provides the concise descriptions of the basic and clinical knowledge about Acanthamoba keratitis, including characteristics of pathogen, risk factors, clinical manifestations, diagnosis and treatment with abundant figure illustrations and typical cases to ophthalmological practitioners and researchers. Acanthamoeba pathogen is widely distributed in the nature. However, Acanthamoeba keratitis is generally considered as a type of sight-threatening keratitis that is difficult to treat. At early stage Acanthamoeba keratitis usually shows atypical clinical manifestations, that are often misdiagnosed as viral or bacterial keratitis. Moreover, there are not approved topical anti-amoebicdrugs available up to now. We hope ophthalmological practitioners can obtain a comprehensive understanding of this infection through this book. Xuguang Sun is a professor of Ophthalmology at Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
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