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    About

Cell

Elsevier

1974-

ISSN: 0092-8674 (1097-4172)
Biochemistry & Molecular Biology - Cell Biology - General Biochemistry, Genetics and Molecular Biology
APC costs unknown

Recent articles

1 show abstract
2019-03-28
Host-attached enteropathogenic E. coli can extract nutrients from mammalian host cells via the CORE protein complex, a platform for membranous nanotube structure formation.
2 show abstract
2019-03-28
Simultaneous recordings of ensembles of individual neurons in the neocortex and cerebellum provide a view of how these two brain regions learn together.
3 show abstract
2019-03-28
Adult hippocampal neurogenesis is a continuous process from development with shared embryonic dentate neural progenitors in mice.
4 show abstract
2019-04-02
It is a great honor for me to receive the prestigious Gairdner Award for Biomedical Research. The title of this essay might imply that it will contain advice on how to win such a major scientific prize. However, my intention is quite different. More in keeping with the famous civil rights song of the same name, my hope is to articulate a bigger picture view of what matters in the long run. Why do we do science' What is fulfilling about a career in science' Is an international prize the pinnacle of success, or are there more important outcomes'
5 show abstract
2019-04-02
One of the 2019 Canada Gairdner International Awards recognizes Timothy Springer’s discovery of the first immune system adhesion molecules involved in lymphocyte homing and the translation of those discoveries into therapeutics for autoimmune disease and cancer.
6 show abstract
2019-04-02
Connie Eaves sets high standards for herself, her science, and her colleagues, which has fueled a stellar career that counts as successes insights into basic stem cell biology, important discoveries in leukemia and breast cancer, and a cohort of trainees that she considers family. Cell editor Lara Szewczak caught up with Connie, the recipient of the 2019 Canada Gairdner Wightman Award, to discuss her dual passions for stem cell biology and mentoring talented young scientists. Annotated excerpts from this conversation are presented below.
7 show abstract
2019-04-02
The 2019 Gairdner Prize will be given to John F.X. Diffley and Bruce Stillman for their groundbreaking work on the mechanisms and control of the initiation of eukaryotic DNA replication. No two people have contributed more extensively, or over a longer period of time, to enlighten us on how our genomes replicate themselves once and only once per cell cycle.
8 show abstract
2019-04-02
When I was finishing up my graduate studies at Brandeis University, my plan was to pursue the field of enzyme kinetics after I received my PhD in biochemistry. But after giving birth to twins 5 days after defending my thesis, I decided my plan required a short-term adjustment. My thesis advisor, professor Nathan O. Kaplan, helped me to find a position that would accommodate a flexible schedule while my boys were young. As a result, I began conducting research in the Department of Pharmacology at Tufts University Medical School, with the expectation that I would move back into my intended field in a few years.
9 show abstract
2019-04-04
Deep sequencing reveals the mutational landscape of human cirrhosis and in vivo CRISPR screening identifies functional roles for recurrently mutated genes in hepatocyte fitness and liver regeneration.
10 show abstract
2019-04-04
A modified CUT&RUN method makes it possible to map chromatin proteins in very low cell numbers, including profiling of several transcription factors in single cells, enabling interrogation of rare cell populations of particular importance in development or disease.
11 show abstract
2019-04-04
Direct interactions between two chaperonins allow them to feed folding substrates bi-directionally between active sites, preventing aggregation and promoting proteostasis.
12 show abstract
2019-04-04
Pancreatic cancer stem cells co-opt immuno-regulatory pathways, a vulnerability that could be exploited therapeutically by agents currently in trials for autoimmune diseases.
13 show abstract
2019-04-04
Stem cell activation and regeneration after tissue damage in Arabidopsis roots is mediated by a jasmonate signaling network.
14 show abstract
2019-04-04
The examination of de novo engineered L1 retrotransposition events in cultured human cells reveals that L1 endonuclease activity and DNA replication dictate L1 insertion preferences and promote its widespread integration throughout the human genome.
15 show abstract
2019-04-04
Insulin receptor translocates from the cell surface to the nucleus, where it associates with transcriptional machinery at promoters, and regulates genes linked to insulin functions.
16 show abstract
2019-04-04
In order to maintain homeostasis, tissue-resident macrophages surround and hide very small tissue lesions to prevent excess inflammation driven by neutrophils.
17 show abstract
2019-04-04
Engineering GPCR-based signaling in yeast allows exploration of signaling properties and creation of synthetic responses to a range of ligands.
18 show abstract
2019-04-04
Across organisms, the key autophagy protein ATG8/LC3 binds a group of proteins on a site distinct from its classical interacting region, raising the possibility of dual binding interactions and identifying an array of previously unknown selective autophagic adaptors and receptors, including some involved in human disease.
19 show abstract
2019-04-04
A subtype of conventional dendritic cells, cDC2, are able to prime CD4+ T cells for antitumor functions and the presence of cDC2 in human cancer samples may serve as a predictive biomarker for survival and response to immune checkpoint blockade.
20 show abstract
2019-04-04
Coupling transcription of a long noncoding RNA to DNA demethylation ensures stochastic promoter choice for clustered Protocadherin α genes, which is essential for the establishment of a neuronal surface identity code involved in circuit assembly.
21 show abstract
2019-04-11
Human pluripotent founder cells within stem cell cultures share hallmark properties with primitive endoderm and reside exclusively at colony boundaries.
22 show abstract
2019-04-11
A new volumetric calcium imaging method called hybrid multiplexed sculpted light microscopy (HyMS) opens up the window to record neuronal activity of more than 10,000 neurons over the entire cortical depth and within the hippocampus of awake and behaving mice.
23 show abstract
2019-04-11
A systematic look at mammalian promoters reveals that lamina-associated domains inherently repress transcription and also gives the first clues as to what dictates whether a gene can escape such silencing.
24 show abstract
2019-04-11
Synchronization of the cell cycle in syncytial Drosophila embryos is controlled by a self-organized mechanism that drives accurate nuclear positioning by integrating localized cell-cycle oscillations, actomyosin cortical contractility, and cytoplasmic flows.
25 show abstract
2019-04-11
A single-cell atlas of cancer and immune cells reveals distinct tumor ecosystems across breast cancer patients, informing prognosis and, potentially, therapy selection.
26 show abstract
2019-04-11
The effects of a range of environmental mutagens in terms of the kinds of mutations they induce and how these are repaired by the cell is presented in the form of a resource.
27 show abstract
2019-04-11
Many proteins that are able to undergo phase transitions contain repeats rich in hydrophobic residues. By contrast, yeast ataxin-2 condensates rely on an abundance of methionines, providing a means for redox-sensitive regulation of its material properties.
28 show abstract
2019-04-11
Unpacking the role of yeast ataxin-2 reveals that it preserves mitochondrial homeostasis, undergoing a condition-sensitive phase transition to modulate TORC1 function.
29 show abstract
2019-04-11
When monkeys observe and learn from each other’s choices, neurons in the amygdala spontaneously encode decision computations to simulate the social partner’s choices.
30 show abstract
2019-04-10
Genome sequences from Island Southeast Asia suggest two independent Denisovan lineages, distinct from the Altai Denisovan, that have contributed to modern Papuan genomes, with one group potentially present east of the Wallace Line and thus capable of crossing geographical barriers.
31 show abstract
2019-04-18
Metabolites produced by the human microbiota can function as agonists for a wide range of G protein-coupled receptors, making metabolome screening a useful tool to both de-orphanize human GPCRs and identify metabolic exchanges between commensal microbes in the gut with effects on host physiology.
32 show abstract
2019-04-18
The E3 ligase RIPLET activates RIG-I via dual ubiquitin-dependent and -independent mechanisms that together work to discriminate the length of dsRNA sensed by RIG-I.
33 show abstract
2019-04-18
Synthetic refactoring makes naturally occurring regulatory systems more amenable to manipulation by removing or recoding their natural genetic complexity. Shaw et al. apply this technique to the yeast mating response pathway, creating a simplified, highly engineerable signaling module that can be used to construct precisely optimized, application-specific GPCR biosensors.
34 show abstract
2019-04-18
In this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.
35 show abstract
2019-04-18
Obesity is one of the most serious health challenges of our time. In this issue of Cell, Khera and co-authors demonstrate the striking ability of genetics, in the form of a polygenic risk score, to identify those individuals at high risk for obesity. This genetic risk expresses itself early as childhood obesity, reinforcing the notion that early prevention is essential to combatting the obesity epidemic.
36 show abstract
2019-04-18
Gain-of-function genetic variants in the Melanocortin-4 Receptor associated with protection against obesity exhibit signaling bias for the recruitment of β-arrestin rather than canonical Gαs-mediated cAMP production.
37 show abstract
2019-04-18
A comparative analysis of 18 rodent species identifies a role for SIRT6-dependent DNA double strand break repair as a major factor in organismal lifespan
38 show abstract
2019-04-18
In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell “macrolesions” are characteristically pro-inflammatory, resident macrophages can “cloak” single-cell microlesions to prevent excessive neutrophil recruitment and limit subsequent tissue damage.
39 show abstract
2019-04-18
Post-translational protein sequence editing dependent on deglycosylation of N-glycosylated asparagine residues regulates proteasome function in C. elegans.
40 show abstract
2019-04-18
A genome-wide polygenic score quantifies inherited susceptibility to obesity, integrating information from 2.1 million common genetic variants to identify adults at risk of severe obesity.
41 show abstract
2019-04-18
This Review provides a comprehensive overview of our current understanding of B cells and the antibodies they produce, at the cellular and molecular level, and their roles in protective immunity and disease.

Green Open Access

Sherpa/Romeo info

Author can archive pre-print (ie pre-refereeing)
Author can (with restrictions) archive post-print (ie final draft post-refereeing) (12 months embargo)
Author cannot archive publisher's version/PDF
  • Author's pre-prints on ArXiv, bioRxiv or BioRN
  • On non-commercial hosting platforms including institutional repository
  • Published source must be acknowledged
  • Must link to journal homepage with DOI
  • Publisher's version/PDF cannot be used
  • Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License
  • Publisher last reviewed on 05/08/2015


More Sherpa/Romeo information

APC Discount

For this journal no deals have been made concerning APC discount

More information on Open Access publishing

Impact

Journal Citation Reports (2017)

Impact factor: 31.398
Q1 (Biochemistry & Molecular Biology (2/292))
Q1 (Cell Biology (3/190))

Scopus Journal Metrics (2017)

SJR: 25.137
SNIP: 5.008
Impact (Scopus CiteScore): 2.199
Quartile: Q1
CiteScore percentile: 99%
CiteScore rank: 1 out of 186
Cited by WUR staff: 1102 times. (2014-2016)

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