WUR Journal browser

WUR Journal browser

  • external user (warningwarning)
  • Log in as
  • The Journal Browser provides a list of more than 30,000 journals. It can be consulted by authors who wish to select a journal for publishing their manuscript Open Access. The information in this list is aggregated from several sources on a regular basis:

    • A list of journals for which the Association of Universities in the Netherlands (VSNU) has made deals with publishers, to make articles Open Access. Under these deals, corresponding authors of Dutch universities can publish their articles Open Access in the participating journals with discounts on the article processing charges (APCs).
    • A list of journals covered by the Journal Citation Reports.
    • A list of journals covered by Scopus.
    • Journals indexed in the Directory of Open Access Journals (DOAJ).
    • Lists of journals for which specific Dutch universities have made deals with publishers, to make articles Open Access. Under these deals, corresponding authors of these universities can publish their articles Open Access in the participating journals with discounts on the article processing charges (APCs). Depending on the university from which the Journal Browser is consulted, this information is shown.
    • Additional data on citations made to journals, in articles published by staff from a specific Dutch university, that are made available by that university. Depending on the university from which the Journal Browser is consulted, this information is shown.

    In the Journal Browser, a search box can be used to look up journals on certain subjects. The terms entered in this box are used to search the journal titles and other metadata (e.g. keywords).

    After having selected journals by subject, it is possible to apply additional filters. These concern no/full costs and discounts for Open Access publishing, support on Open Access publishing in journals, and the quartile to which the journal’s impact factor belongs.

    When one selects a journal in the Journal Browser, the following information may be presented:

    • General information about the selected journal such as title and ISSNs, together with a link to the journal’s website.
    • APC discount that holds for the selected journal if it is part of an Open Access deal.
    • Impact measures for the selected journal from Journal Citation Reports or Scopus. The impact measures that are shown may vary, depending on the university from which the Journal Browser is consulted. For some universities, the number of citations made to the selected journal (in articles published by staff from that university) is also shown.
    • Information from Sherpa/Romeo on the conditions under which articles from the selected journal may be made available via Green Open Access.
    • A listing of articles recently published in the selected journal.
    • For some universities, information is available on what journals have been co-cited most frequently together with the selected journal (in articles published by staff from these universities). When available, this information is presented under ‘similar journals’.
    About

Science

American Association for the Advancement of Science

1880-

ISSN: 0036-8075 (1095-9203)
Multidisciplinary Sciences - Multidisciplinary - Multidisciplinary
APC costs unknown

Recent articles

1 show abstract
2018-09-13T10:37:31-07:00
Authors: Baillie, J ; Zhang ; Y.-P.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1051?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1051 1051
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
2 show abstract
2018-09-13T10:37:31-07:00

Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1052?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1052 1053
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
3 show abstract
2018-09-13T10:37:31-07:00
Authors: Cho ; A.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1054?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1054 1055
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
4 show abstract
2018-09-13T10:37:31-07:00
Authors: Cohen ; J.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1055?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1055 1056
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
5 show abstract
2018-09-13T10:37:31-07:00
Authors: Leslie ; M.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1056?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1056 1057
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
6 show abstract
2018-09-13T10:37:31-07:00
Authors: Voosen ; P.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1058?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1058 1058
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
7 show abstract
2018-09-13T10:37:31-07:00
Authors: Lawler ; A.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1059?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1059 1059
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
8 show abstract
2018-09-13T10:37:31-07:00
Authors: Plautz ; J.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1060?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1060 1063
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
9 show abstract
2018-09-13T10:37:31-07:00
Authors: Amandolare ; S.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1064?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1064 1065
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
10 show abstract
2018-09-13T10:37:31-07:00
Authors: Lenton, T. M ; Latour ; B.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1066?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1066 1068
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
11 show abstract
2018-09-13T10:37:31-07:00
Authors: Muday, G. K ; Brown-Harding ; H.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1068?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1068 1069
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
12 show abstract
2018-09-13T10:37:31-07:00
Authors: Modesti ; M.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1069?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1069 1070
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
13 show abstract
2018-09-13T10:37:31-07:00
Authors: Lancaster ; K. M.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1071?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1071 1072
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
14 show abstract
2018-09-13T10:37:31-07:00
Authors: Riva ; R.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1072?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1072 1073
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
15 show abstract
2018-09-13T10:37:31-07:00
Authors: Ruffier ; F.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1073?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1073 1074
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
16 show abstract
2018-09-13T10:37:31-07:00
Authors: Beuse, M ; Schmidt ; T. S ; Wood ; V.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1075?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1075 1077
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
17 show abstract
2018-09-13T10:37:31-07:00
Authors: Kemp ; C.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1078?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1078 1078
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
18 show abstract
2018-09-13T10:37:31-07:00
Authors: Robinson ; A.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1079?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1079 1079
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
19 show abstract
2018-09-13T10:37:31-07:00
Authors: Demmer, R ; Beschta ; R. L.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1081-a?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1081 1081
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
20 show abstract
2018-09-13T10:37:31-07:00
Authors: Lyons, P. B ; Kotek ; J. F.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1081-b?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1081 1082
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
21 show abstract
2018-09-13T10:37:31-07:00
Authors: Smith, K. R ; Woodward ; A ; Haines ; A ; Chafe ; Z.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1082?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1082 1082
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
22 show abstract
2018-09-13T10:37:31-07:00
Authors: Vignieri ; S.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-a?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1083
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
23 show abstract
2018-09-13T10:37:31-07:00
Authors: Funk ; M. A.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-b?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1083
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
24 show abstract
2018-09-13T10:37:31-07:00
Authors: Lavine ; M. S.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-c?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1083
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
25 show abstract
2018-09-13T10:37:31-07:00
Authors: Vinson ; V.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-d?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1083
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
26 show abstract
2018-09-13T10:37:31-07:00
Authors: Sugden ; A. M.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-e?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1083
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
27 show abstract
2018-09-13T10:37:31-07:00
Authors: Mao ; S.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-f?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1084
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
28 show abstract
2018-09-13T10:37:31-07:00
Authors: Osborne ; I. S.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-g?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1084
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
29 show abstract
2018-09-13T10:37:31-07:00
Authors: Benson ; P. J.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-h?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1084
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
30 show abstract
2018-09-13T10:37:31-07:00
Authors: Maroso ; M.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-i?rss=1
Citation: Vol 361 No. 6407 (2018) pp i 1084
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
31 show abstract
2018-09-13T10:37:31-07:00
Authors: Scanlon ; S. T.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-j?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
32 show abstract
2018-09-13T10:37:31-07:00
Authors: Yeston ; J.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-k?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
33 show abstract
2018-09-13T10:37:31-07:00
Authors: Stern ; P.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-l?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
34 show abstract
2018-09-13T10:37:31-07:00
Authors: Szuromi ; P.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-m?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
35 show abstract
2018-09-13T10:37:31-07:00
Authors: Hurtley ; S. M.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-n?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
36 show abstract
2018-09-13T10:37:31-07:00
Authors: Fahrenkamp-Uppenbrink ; J.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-o?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
37 show abstract
2018-09-13T10:37:31-07:00
Authors: Ferrarelli ; L. K.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-p?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
38 show abstract
2018-09-13T10:37:31-07:00
Authors: Balasubramani ; A.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-q?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
39 show abstract
2018-09-13T10:37:31-07:00
Authors: Hines ; P. J.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1083-r?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1083 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
40 show abstract
2018-09-13T10:37:31-07:00
Authors: Sugden ; A. M.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1084-a?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1084 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
41 show abstract
2018-09-13T10:37:31-07:00
Authors: Kiberstis ; P. A.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1084-b?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1084 1084
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
42 show abstract
2018-09-13T10:37:31-07:00
Authors: Kelly ; P. N.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1084-c?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1084 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
43 show abstract
2018-09-13T10:37:31-07:00
Authors: Hurtley ; S. M.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1084-d?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1084 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
44 show abstract
2018-09-13T10:37:31-07:00
Authors: Stajic ; J.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1084-e?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1084 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
45 show abstract
2018-09-13T10:37:31-07:00
Authors: Fahrenkamp-Uppenbrink ; J.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1084-f?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1084 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
46 show abstract
2018-09-13T10:37:31-07:00
Authors: Funk ; M. A.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1084-g?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1084 1085
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
47 show abstract
2018-09-13T10:37:31-07:00
Insects are among the most agile natural flyers. Hypotheses on their flight control cannot always be validated by experiments with animals or tethered robots. To this end, we developed a programmable and agile autonomous free-flying robot controlled through bio-inspired motion changes of its flapping wings. Despite being 55 times the size of a fruit fly, the robot can accurately mimic the rapid escape maneuvers of flies, including a correcting yaw rotation toward the escape heading. Because the robot’s yaw control was turned off, we showed that these yaw rotations result from passive, translation-induced aerodynamic coupling between the yaw torque and the roll and pitch torques produced throughout the maneuver. The robot enables new methods for studying animal flight, and its flight characteristics allow for real-world flight missions.
48 show abstract
2018-09-13T10:37:31-07:00
Although organic photovoltaic (OPV) cells have many advantages, their performance still lags far behind that of other photovoltaic platforms. A fundamental reason for their low performance is the low charge mobility of organic materials, leading to a limit on the active-layer thickness and efficient light absorption. In this work, guided by a semi-empirical model analysis and using the tandem cell strategy to overcome such issues, and taking advantage of the high diversity and easily tunable band structure of organic materials, a record and certified 17.29% power conversion efficiency for a two-terminal monolithic solution-processed tandem OPV is achieved.
49 show abstract
2018-09-13T10:37:31-07:00
Multielectron redox reactions often require multicofactor metalloenzymes to facilitate coupled electron and proton movement, but it is challenging to design artificial enzymes to catalyze these important reactions, owing to their structural and functional complexity. We report a designed heteronuclear heme-[4Fe-4S] cofactor in cytochrome c peroxidase as a structural and functional model of the enzyme sulfite reductase. The initial model exhibits spectroscopic and ligand-binding properties of the native enzyme, and sulfite reduction activity was improved—through rational tuning of the secondary sphere interactions around the [4Fe-4S] and the substrate-binding sites—to be close to that of the native enzyme. By offering insight into the requirements for a demanding six-electron, seven-proton reaction that has so far eluded synthetic catalysts, this study provides strategies for designing highly functional multicofactor artificial enzymes.
50 show abstract
2018-09-13T10:37:31-07:00
Metamaterials constructed from deep subwavelength building blocks have been used to demonstrate phenomena ranging from negative refractive index and -near-zero to cloaking, emulations of general relativity, and superresolution imaging. More recently, metamaterials have been suggested as a new platform for quantum optics. We present the use of a dielectric metasurface to generate entanglement between the spin and orbital angular momentum of photons. We demonstrate the generation of the four Bell states on a single photon by using the geometric phase that arises from the photonic spin-orbit interaction and subsequently show nonlocal correlations between two photons that interacted with the metasurface. Our results show that metamaterials are suitable for the generation and manipulation of entangled photon states, introducing the area of quantum optics metamaterials.
51 show abstract
2018-09-13T10:37:31-07:00
Metasurfaces based on resonant nanophotonic structures have enabled innovative types of flat-optics devices that often outperform the capabilities of bulk components, yet these advances remain largely unexplored for quantum applications. We show that nonclassical multiphoton interferences can be achieved at the subwavelength scale in all-dielectric metasurfaces. We simultaneously image multiple projections of quantum states with a single metasurface, enabling a robust reconstruction of amplitude, phase, coherence, and entanglement of multiphoton polarization-encoded states. One- and two-photon states are reconstructed through nonlocal photon correlation measurements with polarization-insensitive click detectors positioned after the metasurface, and the scalability to higher photon numbers is established theoretically. Our work illustrates the feasibility of ultrathin quantum metadevices for the manipulation and measurement of multiphoton quantum states, with applications in free-space quantum imaging and communications.
52 show abstract
2018-09-13T10:37:31-07:00
Global maps of forest loss depict the scale and magnitude of forest disturbance, yet companies, governments, and nongovernmental organizations need to distinguish permanent conversion (i.e., deforestation) from temporary loss from forestry or wildfire. Using satellite imagery, we developed a forest loss classification model to determine a spatial attribution of forest disturbance to the dominant drivers of land cover and land use change over the period 2001 to 2015. Our results indicate that 27% of global forest loss can be attributed to deforestation through permanent land use change for commodity production. The remaining areas maintained the same land use over 15 years; in those areas, loss was attributed to forestry (26%), shifting agriculture (24%), and wildfire (23%). Despite corporate commitments, the rate of commodity-driven deforestation has not declined. To end deforestation, companies must eliminate 5 million hectares of conversion from supply chains each year.
53 show abstract
2018-09-13T10:37:31-07:00
Animals require rapid, long-range molecular signaling networks to integrate sensing and response throughout their bodies. The amino acid glutamate acts as an excitatory neurotransmitter in the vertebrate central nervous system, facilitating long-range information exchange via activation of glutamate receptor channels. Similarly, plants sense local signals, such as herbivore attack, and transmit this information throughout the plant body to rapidly activate defense responses in undamaged parts. Here we show that glutamate is a wound signal in plants. Ion channels of the GLUTAMATE RECEPTOR–LIKE family act as sensors that convert this signal into an increase in intracellular calcium ion concentration that propagates to distant organs, where defense responses are then induced.
54 show abstract
2018-09-13T10:37:31-07:00
Billions of animals cross the globe each year during seasonal migrations, but efforts to monitor them are hampered by the unpredictability of their movements. We developed a bird migration forecast system at a continental scale by leveraging 23 years of spring observations to identify associations between atmospheric conditions and bird migration intensity. Our models explained up to 81% of variation in migration intensity across the United States at altitudes of 0 to 3000 meters, and performance remained high in forecasting events 1 to 7 days in advance (62 to 76% of variation was explained). Avian migratory movements across the United States likely exceed 500 million individuals per night during peak passage. Bird migration forecasts will reduce collisions with buildings, airplanes, and wind turbines; inform a variety of monitoring efforts; and engage the public.
55 show abstract
2018-09-13T10:37:31-07:00
The majority of organellar proteins are translated on cytosolic ribosomes and must be sorted correctly to function. Targeting routes have been identified for organelles such as peroxisomes and the endoplasmic reticulum (ER). However, little is known about the initial steps of targeting of mitochondrial proteins. In this study, we used a genome-wide screen in yeast and identified factors critical for the intracellular sorting of the mitochondrial inner membrane protein Oxa1. The screen uncovered an unexpected path, termed ER-SURF, for targeting of mitochondrial membrane proteins. This pathway retrieves mitochondrial proteins from the ER surface and reroutes them to mitochondria with the aid of the ER-localized chaperone Djp1. Hence, cells use the expanse of the ER surfaces as a fail-safe to maximize productive mitochondrial protein targeting.
56 show abstract
2018-09-13T10:37:31-07:00
Monitoring metabolites at the point of care could improve the diagnosis and management of numerous diseases. Yet for most metabolites, such assays are not available. We introduce semisynthetic, light-emitting sensor proteins for use in paper-based metabolic assays. The metabolite is oxidized by nicotinamide adenine dinucleotide phosphate, and the sensor changes color in the presence of the reduced cofactor, enabling metabolite quantification with the use of a digital camera. The approach makes any metabolite that can be oxidized by the cofactor a candidate for quantitative point-of-care assays, as shown for phenylalanine, glucose, and glutamate. Phenylalanine blood levels of phenylketonuria patients were analyzed at the point of care within minutes with only 0.5 microliters of blood. Results were within 15% of those obtained with standard testing methods.
57 show abstract
2018-09-13T10:37:31-07:00
The nonhomologous end–joining (NHEJ) pathway preserves genome stability by ligating the ends of broken chromosomes together. It employs end-processing enzymes, including polymerases, to prepare ends for ligation. We show that two such polymerases incorporate primarily ribonucleotides during NHEJ—an exception to the central dogma of molecular biology—both during repair of chromosome breaks made by Cas9 and during V(D)J recombination. Moreover, additions of ribonucleotides but not deoxynucleotides effectively promote ligation. Repair kinetics suggest that ribonucleotide-dependent first-strand ligation is followed by complementary strand repair with deoxynucleotides, then by replacement of ribonucleotides embedded in the first strand with deoxynucleotides. Our results indicate that as much as 65% of cellular NHEJ products have transiently embedded ribonucleotides, which promote flexibility in repair at the cost of more fragile intermediates.
58 show abstract
2018-09-13T10:37:31-07:00

Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1130?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1130 1130
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
59 show abstract
2018-09-13T10:37:31-07:00
Authors: Bibic ; L.
Article URL: http://science.sciencemag.org/cgi/content/short/361/6407/1158?rss=1
Citation: Vol 361 No. 6407 (2018) pp 1158 1158
Publication Date: 2018-09-13T10:37:31-07:00
Journal: Science
60 show abstract
2018-09-13T10:37:31-07:00
In response to infection, naïve CD4+ T cells differentiate into two subpopulations: T follicular helper (TFH) cells, which support B cell antibody production, and non-TFH cells, which enhance innate immune cell functions. Interleukin-2 (IL-2), the major cytokine produced by naïve T cells, plays an important role in the developmental divergence of these populations. However, the relationship between IL-2 production and fate determination remains unclear. Using reporter mice, we found that differential production of IL-2 by naïve CD4+ T cells defined precursors fated for different immune functions. IL-2 producers, which were fated to become TFH cells, delivered IL-2 to nonproducers destined to become non-TFH cells. Because IL-2 production was limited to cells receiving the strongest T cell receptor (TCR) signals, a direct link between TCR-signal strength, IL-2 production, and T cell fate determination has been established.
61 show abstract
2018-09-13T10:37:31-07:00
Animals rely on olfaction to find food, attract mates, and avoid predators. To support these behaviors, they must be able to identify odors across different odorant concentrations. The neural circuit operations that implement this concentration invariance remain unclear. We found that despite concentration-dependence in the olfactory bulb (OB), representations of odor identity were preserved downstream, in the piriform cortex (PCx). The OB cells responding earliest after inhalation drove robust responses in sparse subsets of PCx neurons. Recurrent collateral connections broadcast their activation across the PCx, recruiting global feedback inhibition that rapidly truncated and suppressed cortical activity for the remainder of the sniff, discounting the impact of slower, concentration-dependent OB inputs. Eliminating recurrent collateral output amplified PCx odor responses rendered the cortex steeply concentration-dependent and abolished concentration-invariant identity decoding.
62 show abstract
2018-09-13T10:37:31-07:00
The Ugi reaction constructs α-acylaminoamide compounds by combining an aldehyde or ketone, an amine, a carboxylic acid, and an isocyanide in a single flask. Its appealing features include inherent atom and step economy together with the potential to generate products of broad structural diversity. However, control of the stereochemistry in this reaction has proven to be a formidable challenge. We describe an efficient enantioselective four-component Ugi reaction catalyzed by a chiral phosphoric acid derivative that delivers more than 80 α-acylaminoamides in good to excellent enantiomeric excess. Experimental and computational studies establish the reaction mechanism and origins of stereoselectivity.
63 show abstract
2018-09-13T10:37:31-07:00
Nie and colleagues suggest a key role for interannual climate variation as an explanation for the temporal dynamics of an unexpected 20-year reversal of biomass responses of C3-C4 grasses to elevated CO2. However, we had already identified some climate-dependent differences in C3 and C4 responses to eCO2 and shown that these could not fully explain the temporal dynamics we observed.

Green Open Access

Sherpa/Romeo info

Author can archive pre-print (ie pre-refereeing)
Author can archive post-print (ie final draft post-refereeing)
Author cannot archive publisher's version/PDF
  • Pre-print may be considered prior publication
  • Pre-print on not-for-profit preprint servers where allowed, please contact editors for clarification
  • Cannot archive until publication
  • Authors retain copyright
  • On author's personal website or institutional repository
  • Publisher's version/PDF cannot be used
  • Must link to publisher version
  • Set statement must accompany post-print (see policy)
  • Published source must be acknowledged with DOI
  • Authors covered by funding agency rules, may post author's post-print in PubMed Central or funder's designated repository after a 6 month embargo
  • Authors covered by funding agency rules, must state on submission, for article to be released in PubMed Central or funder's designated repository after 6 months after publication.


More Sherpa/Romeo information

APC Discount

For this journal no deals have been made concerning APC discount

More information on Open Access publishing

Impact

Journal Citation Reports (2017)

Impact factor: 41.058
Q1 (Multidisciplinary Sciences (2/64))

Scopus Journal Metrics (2016)

SJR: 13.535
SNIP: 7.688
Impact (Scopus CiteScore): 1.439
Quartile: Q1
CiteScore percentile: 99%
CiteScore rank: 1 out of 77
Cited by WUR staff: 6112 times. (2014-2016)

Similar journals  

 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.