WUR Journal browser

WUR Journal browser

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  • The Journal Browser provides a list of more than 30,000 journals. It can be consulted by authors who wish to select a journal for publishing their manuscript Open Access. The information in this list is aggregated from several sources on a regular basis:

    • A list of journals for which the Association of Universities in the Netherlands (VSNU) has made deals with publishers, to make articles Open Access. Under these deals, corresponding authors of Dutch universities can publish their articles Open Access in the participating journals with discounts on the article processing charges (APCs).
    • A list of journals covered by the Journal Citation Reports.
    • A list of journals covered by Scopus.
    • Journals indexed in the Directory of Open Access Journals (DOAJ).
    • Lists of journals for which specific Dutch universities have made deals with publishers, to make articles Open Access. Under these deals, corresponding authors of these universities can publish their articles Open Access in the participating journals with discounts on the article processing charges (APCs). Depending on the university from which the Journal Browser is consulted, this information is shown.
    • Additional data on citations made to journals, in articles published by staff from a specific Dutch university, that are made available by that university. Depending on the university from which the Journal Browser is consulted, this information is shown.

    In the Journal Browser, a search box can be used to look up journals on certain subjects. The terms entered in this box are used to search the journal titles and other metadata (e.g. keywords).

    After having selected journals by subject, it is possible to apply additional filters. These concern no/full costs and discounts for Open Access publishing, support on Open Access publishing in journals, and the quartile to which the journal’s impact factor belongs.

    When one selects a journal in the Journal Browser, the following information may be presented:

    • General information about the selected journal such as title and ISSNs, together with a link to the journal’s website.
    • APC discount that holds for the selected journal if it is part of an Open Access deal.
    • Impact measures for the selected journal from Journal Citation Reports or Scopus. The impact measures that are shown may vary, depending on the university from which the Journal Browser is consulted. For some universities, the number of citations made to the selected journal (in articles published by staff from that university) is also shown.
    • Information from Sherpa/Romeo on the conditions under which articles from the selected journal may be made available via Green Open Access.
    • A listing of articles recently published in the selected journal.
    • For some universities, information is available on what journals have been co-cited most frequently together with the selected journal (in articles published by staff from these universities). When available, this information is presented under ‘similar journals’.
    About

Science

American Association for the Advancement of Science

1880-

ISSN: 0036-8075 (1095-9203)
Multidisciplinary Sciences - Multidisciplinary - Multidisciplinary
APC costs unknown

Recent articles

1 show abstract
2018-12-06T10:38:28-08:00
Authors: Kasparov G.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1087?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1087 1087
Publication Date: 2018-12-06T10:38:28-08:00
Journal: Science
2 show abstract
2018-12-06T10:38:28-08:00

Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1088?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1088 1089
Publication Date: 2018-12-06T10:38:28-08:00
Journal: Science
3 show abstract
2018-12-06T10:38:28-08:00
Authors: Cohen J.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1090?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1090 1092
Publication Date: 2018-12-06T10:38:28-08:00
Journal: Science
4 show abstract
2018-12-06T10:38:28-08:00
Authors: Normile D.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1091?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1091 1091
Publication Date: 2018-12-06T10:38:28-08:00
Journal: Science
5 show abstract
2018-12-06T10:38:28-08:00
Authors: Stokstad E.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1092?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1092 1093
Publication Date: 2018-12-06T10:38:28-08:00
Journal: Science
6 show abstract
2018-12-06T10:38:28-08:00
Authors: Cohen J.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1094?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1094 1094
Publication Date: 2018-12-06T10:38:28-08:00
Journal: Science
7 show abstract
2018-12-06T10:38:28-08:00
Authors: Vogel G.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1095?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1095 1095
Publication Date: 2018-12-06T10:38:28-08:00
Journal: Science
8 show abstract
2018-12-06T10:38:28-08:00
Authors: Wadman M.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1096?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1096 1099
Publication Date: 2018-12-06T10:38:28-08:00
Journal: Science
9 show abstract
2018-12-06T10:38:28-08:00
Authors: Piller C.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1100?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1100 1103
Publication Date: 2018-12-06T10:38:28-08:00
Journal: Science
10 show abstract
2018-12-06T10:38:28-08:00
Authors: Ash, C ; Stajic ; J ; Lavine ; M. S ; Scanlon ; S ; Ucko ; H. N ; Ucko ; S. N ; Nusinovich ; Y ; Vignieri ; S. N ; Rai ; T ; Sills ; J ; Mao ; S ; Vignieri ; S. N ; Fahrenkamp-Uppenbrink ; J ; Sills ; J ; Lavine ; M. S ; Lavine ; M. S ; Grocholski ; B ; Funk ; M ; Kmec ; L ; Zahn ; L. M ; Smith ; K. T ; Riley ; D ; Vignieri ; S. N.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1104?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1104 1110
Publication Date: 2018-12-06T10:38:28-08:00
Journal: Science
11 show abstract
2018-12-06T10:38:29-08:00
Authors: Kahr, B ; Ward ; M. D.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1111?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1111 1111
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
12 show abstract
2018-12-06T10:38:29-08:00
Authors: Phillips, M. A ; Goldberg ; D. E.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1112?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1112 1113
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
13 show abstract
2018-12-06T10:38:29-08:00
Authors: Kump L.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1113?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1113 1114
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
14 show abstract
2018-12-06T10:38:29-08:00
Authors: Schon E. A.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1114?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1114 1115
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
15 show abstract
2018-12-06T10:38:29-08:00
Authors: Gomez-Salinero, J. M ; Rafii ; S.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1116?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1116 1117
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
16 show abstract
2018-12-06T10:38:29-08:00
Authors: Campbell M.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1118?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1118 1118
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
17 show abstract
2018-12-06T10:38:29-08:00
Authors: Bento, A. M ; Gillingham ; K ; Jacobsen ; M. R ; Knittel ; C. R ; Leard ; B ; Linn ; J ; McConnell ; V ; Rapson ; D ; Sallee ; J. M ; van Benthem ; A. A ; Whitefoot ; K. S.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1119?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1119 1121
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
18 show abstract
2018-12-06T10:38:29-08:00
Authors: Parmesan, C ; Hanley ; M. E ; Singer ; M. C.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1122-a?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1122 1122
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
19 show abstract
2018-12-06T10:38:29-08:00
Authors: Deutsch, C. A ; Tewksbury ; J. J ; Merrill ; S. C ; Huey ; R. B ; Battisti ; D. S ; Naylor ; R. L.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1122-b?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1122 1123
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
20 show abstract
2018-12-06T10:38:29-08:00
Authors: Halperin J. L.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1123?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1123 1123
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
21 show abstract
2018-12-06T10:38:29-08:00
Authors: Kiberstis P. A.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-a?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1124
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
22 show abstract
2018-12-06T10:38:29-08:00
Authors: Ash C.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-b?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1124
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
23 show abstract
2018-12-06T10:38:29-08:00
Authors: Zahn L. M.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-c?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1124
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
24 show abstract
2018-12-06T10:38:29-08:00
Authors: Mao S.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-d?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1124
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
25 show abstract
2018-12-06T10:38:29-08:00
Authors: Benson P. J.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-e?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1125
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
26 show abstract
2018-12-06T10:38:29-08:00
Authors: Fogg C. N.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-f?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1125
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
27 show abstract
2018-12-06T10:38:29-08:00
Authors: Stajic J.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-g?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1125
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
28 show abstract
2018-12-06T10:38:29-08:00
Authors: Lavine M. S.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-h?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1125
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
29 show abstract
2018-12-06T10:38:29-08:00
Authors: Osborne I. S.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-i?rss=1
Citation: Vol 362 No. 6419 (2018) pp i 1125
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
30 show abstract
2018-12-06T10:38:29-08:00
Authors: Vignieri S.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-j?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
31 show abstract
2018-12-06T10:38:29-08:00
Authors: Zahn L. M.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-k?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
32 show abstract
2018-12-06T10:38:29-08:00
Authors: Ash C.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-l?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
33 show abstract
2018-12-06T10:38:29-08:00
Authors: Szuromi P.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-m?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
34 show abstract
2018-12-06T10:38:29-08:00
Authors: Vignieri S.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-n?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
35 show abstract
2018-12-06T10:38:29-08:00
Authors: Szuromi P.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-o?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
36 show abstract
2018-12-06T10:38:29-08:00
Authors: Stajic J.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-p?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
37 show abstract
2018-12-06T10:38:29-08:00
Authors: Ray L. B.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-q?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
38 show abstract
2018-12-06T10:38:29-08:00
Authors: Alderton G.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-r?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
39 show abstract
2018-12-06T10:38:29-08:00
Authors: Ray L. B.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-s?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
40 show abstract
2018-12-06T10:38:29-08:00
Authors: Charneski C. A.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-t?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
41 show abstract
2018-12-06T10:38:29-08:00
Authors: Wong W.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1124-u?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1124 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
42 show abstract
2018-12-06T10:38:29-08:00
Authors: Sugden A. M.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1125-a?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1125 1125
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
43 show abstract
2018-12-06T10:38:29-08:00
Authors: Stern P.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1125-b?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1125 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
44 show abstract
2018-12-06T10:38:29-08:00
Authors: Smith H. J.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1125-c?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1125 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
45 show abstract
2018-12-06T10:38:29-08:00
Authors: Hurtley S. M.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1125-d?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1125 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
46 show abstract
2018-12-06T10:38:29-08:00
Authors: Osborne I. S.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1125-e?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1125 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
47 show abstract
2018-12-06T10:38:29-08:00
Authors: Stajic J.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1125-f?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1125 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
48 show abstract
2018-12-06T10:38:29-08:00
Authors: Ash C.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1125-g?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1125 1126
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
49 show abstract
2018-12-06T10:38:29-08:00
Although high-temperature operation (i.e., beyond 150°C) is of great interest for many electronics applications, achieving stable carrier mobilities for organic semiconductors at elevated temperatures is fundamentally challenging. We report a general strategy to make thermally stable high-temperature semiconducting polymer blends, composed of interpenetrating semicrystalline conjugated polymers and high glass-transition temperature insulating matrices. When properly engineered, such polymer blends display a temperature-insensitive charge transport behavior with hole mobility exceeding 2.0 cm2/V·s across a wide temperature range from room temperature up to 220°C in thin-film transistors.
50 show abstract
2018-12-06T10:38:29-08:00
Assembly of two-dimensional (2D) molecular arrays on surfaces produces a wide range of architectural motifs exhibiting unique properties, but little attention has been given to the mechanism by which they nucleate. Using peptides selected for their binding affinity to molybdenum disulfide, we investigated nucleation of 2D arrays by molecularly resolved in situ atomic force microscopy and compared our results to molecular dynamics simulations. The arrays assembled one row at a time, and the nuclei were ordered from the earliest stages and formed without a free energy barrier or a critical size. The results verify long-standing but unproven predictions of classical nucleation theory in one dimension while revealing key interactions underlying 2D assembly.
51 show abstract
2018-12-06T10:38:29-08:00
The game of chess is the longest-studied domain in the history of artificial intelligence. The strongest programs are based on a combination of sophisticated search techniques, domain-specific adaptations, and handcrafted evaluation functions that have been refined by human experts over several decades. By contrast, the AlphaGo Zero program recently achieved superhuman performance in the game of Go by reinforcement learning from self-play. In this paper, we generalize this approach into a single AlphaZero algorithm that can achieve superhuman performance in many challenging games. Starting from random play and given no domain knowledge except the game rules, AlphaZero convincingly defeated a world champion program in the games of chess and shogi (Japanese chess), as well as Go.
52 show abstract
2018-12-06T10:38:29-08:00
Fluoride ion batteries are potential "next-generation" electrochemical storage devices that offer high energy density. At present, such batteries are limited to operation at high temperatures because suitable fluoride ion–conducting electrolytes are known only in the solid state. We report a liquid fluoride ion–conducting electrolyte with high ionic conductivity, wide operating voltage, and robust chemical stability based on dry tetraalkylammonium fluoride salts in ether solvents. Pairing this liquid electrolyte with a copper–lanthanum trifluoride (Cu@LaF3) core-shell cathode, we demonstrate reversible fluorination and defluorination reactions in a fluoride ion electrochemical cell cycled at room temperature. Fluoride ion–mediated electrochemistry offers a pathway toward developing capacities beyond that of lithium ion technology.
53 show abstract
2018-12-06T10:38:29-08:00
Developing alternative paradigms of electronics beyond silicon technology requires the exploration of fundamentally new physical mechanisms, such as the valley-specific phenomena in hexagonal two-dimensional materials. We realize ballistic valley Hall kink states in bilayer graphene and demonstrate gate-controlled current transmission in a four-kink router device. The operations of a waveguide, a valve, and a tunable electron beam splitter are demonstrated. The valley valve exploits the valley-momentum locking of the kink states and reaches an on/off ratio of 8 at zero magnetic field. A magnetic field enables a full-range tunable coherent beam splitter. These results pave a path to building a scalable, coherent quantum transportation network based on the kink states.
54 show abstract
2018-12-06T10:38:29-08:00
Graphene is an atomically thin plasmonic medium that supports highly confined plasmon polaritons, or nano-light, with very low loss. Electronic properties of graphene can be drastically altered when it is laid upon another graphene layer, resulting in a moiré superlattice. The relative twist angle between the two layers is a key tuning parameter of the interlayer coupling in thus-obtained twisted bilayer graphene (TBG). We studied the propagation of plasmon polaritons in TBG by infrared nano-imaging. We discovered that the atomic reconstruction occurring at small twist angles transforms the TBG into a natural plasmon photonic crystal for propagating nano-light. This discovery points to a pathway for controlling nano-light by exploiting quantum properties of graphene and other atomically layered van der Waals materials, eliminating the need for arduous top-down nanofabrication.
55 show abstract
2018-12-06T10:38:29-08:00
Many bacterial infections are hard to treat and tend to relapse, possibly due to the presence of antibiotic-tolerant persisters. In vitro, persister cells appear to be dormant. After uptake of Salmonella species by macrophages, nongrowing persisters also occur, but their physiological state is poorly understood. In this work, we show that Salmonella persisters arising during macrophage infection maintain a metabolically active state. Persisters reprogram macrophages by means of effectors secreted by the Salmonella pathogenicity island 2 type 3 secretion system. These effectors dampened proinflammatory innate immune responses and induced anti-inflammatory macrophage polarization. Such reprogramming allowed nongrowing Salmonella cells to survive for extended periods in their host. Persisters undermining host immune defenses might confer an advantage to the pathogen during relapse once antibiotic pressure is relieved.
56 show abstract
2018-12-06T10:38:29-08:00
We estimated the genome-wide contribution of recessive coding variation in 6040 families from the Deciphering Developmental Disorders study. The proportion of cases attributable to recessive coding variants was 3.6% in patients of European ancestry, compared with 50% explained by de novo coding mutations. It was higher (31%) in patients with Pakistani ancestry, owing to elevated autozygosity. Half of this recessive burden is attributable to known genes. We identified two genes not previously associated with recessive developmental disorders, KDM5B and EIF3F, and functionally validated them with mouse and cellular models. Our results suggest that recessive coding variants account for a small fraction of currently undiagnosed nonconsanguineous individuals, and that the role of noncoding variants, incomplete penetrance, and polygenic mechanisms need further exploration.
57 show abstract
2018-12-06T10:38:29-08:00
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor subtypes, we performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors. We found that patients whose tumors lacked telomere maintenance mechanisms had an excellent prognosis, whereas the prognosis of patients whose tumors harbored telomere maintenance mechanisms was substantially worse. Survival rates were lowest for neuroblastoma patients whose tumors harbored telomere maintenance mechanisms in combination with RAS and/or p53 pathway mutations. Spontaneous tumor regression occurred both in the presence and absence of these mutations in patients with telomere maintenance–negative tumors. On the basis of these data, we propose a mechanistic classification of neuroblastoma that may benefit the clinical management of patients.
58 show abstract
2018-12-06T10:38:29-08:00
In genetic screens aimed at understanding drug resistance mechanisms in chronic myeloid leukemia cells, inactivation of the cullin 3 adapter protein-encoding leucine zipper-like transcription regulator 1 (LZTR1) gene led to enhanced mitogen-activated protein kinase (MAPK) pathway activity and reduced sensitivity to tyrosine kinase inhibitors. Knockdown of the Drosophila LZTR1 ortholog CG3711 resulted in a Ras-dependent gain-of-function phenotype. Endogenous human LZTR1 associates with the main RAS isoforms. Inactivation of LZTR1 led to decreased ubiquitination and enhanced plasma membrane localization of endogenous KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog). We propose that LZTR1 acts as a conserved regulator of RAS ubiquitination and MAPK pathway activation. Because LZTR1 disease mutations failed to revert loss-of-function phenotypes, our findings provide a molecular rationale for LZTR1 involvement in a variety of inherited and acquired human disorders.
59 show abstract
2018-12-06T10:38:29-08:00
The leucine zipper–like transcriptional regulator 1 (LZTR1) protein, an adaptor for cullin 3 (CUL3) ubiquitin ligase complex, is implicated in human disease, yet its mechanism of action remains unknown. We found that Lztr1 haploinsufficiency in mice recapitulates Noonan syndrome phenotypes, whereas LZTR1 loss in Schwann cells drives dedifferentiation and proliferation. By trapping LZTR1 complexes from intact mammalian cells, we identified the guanosine triphosphatase RAS as a substrate for the LZTR1-CUL3 complex. Ubiquitome analysis showed that loss of Lztr1 abrogated Ras ubiquitination at lysine-170. LZTR1-mediated ubiquitination inhibited RAS signaling by attenuating its association with the membrane. Disease-associated LZTR1 mutations disrupted either LZTR1-CUL3 complex formation or its interaction with RAS proteins. RAS regulation by LZTR1-mediated ubiquitination provides an explanation for the role of LZTR1 in human disease.
60 show abstract
2018-12-06T10:38:29-08:00
DNA methylation generally functions as a repressive transcriptional signal, but it is also known to activate gene expression. In either case, the downstream factors remain largely unknown. By using comparative interactomics, we isolated proteins in Arabidopsis thaliana that associate with methylated DNA. Two SU(VAR)3-9 homologs, the transcriptional antisilencing factor SUVH1, and SUVH3, were among the methyl reader candidates. SUVH1 and SUVH3 bound methylated DNA in vitro, were associated with euchromatic methylation in vivo, and formed a complex with two DNAJ domain-containing homologs, DNAJ1 and DNAJ2. Ectopic recruitment of DNAJ1 enhanced gene transcription in plants, yeast, and mammals. Thus, the SUVH proteins bind to methylated DNA and recruit the DNAJ proteins to enhance proximal gene expression, thereby counteracting the repressive effects of transposon insertion near genes.
61 show abstract
2018-12-06T10:38:29-08:00
Lipid composition determines the physical properties of biological membranes and can vary substantially between and within organisms. We describe a specific role for the viscosity of energy-transducing membranes in cellular respiration. Engineering of fatty acid biosynthesis in Escherichia coli allowed us to titrate inner membrane viscosity across a 10-fold range by controlling the abundance of unsaturated or branched lipids. These fluidizing lipids tightly controlled respiratory metabolism, an effect that can be explained with a quantitative model of the electron transport chain (ETC) that features diffusion-coupled reactions between enzymes and electron carriers (quinones). Lipid unsaturation also modulated mitochondrial respiration in engineered budding yeast strains. Thus, diffusion in the ETC may serve as an evolutionary constraint for lipid composition in respiratory membranes.
62 show abstract
2018-12-06T10:38:29-08:00

Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1193-a?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1193 1193
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
63 show abstract
2018-12-06T10:38:29-08:00
Authors: Schubert C.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1193-b?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1193 1193
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
64 show abstract
2018-12-06T10:38:29-08:00
Authors: Frater, P. N ; Sullivan ; L. L.
Article URL: http://science.sciencemag.org/cgi/content/short/362/6419/1206?rss=1
Citation: Vol 362 No. 6419 (2018) pp 1206 1206
Publication Date: 2018-12-06T10:38:29-08:00
Journal: Science
65 show abstract
2018-12-06T10:38:29-08:00
Rapid climate change at the end of the Permian Period (~252 million years ago) is the hypothesized trigger for the largest mass extinction in Earth’s history. We present model simulations of the Permian/Triassic climate transition that reproduce the ocean warming and oxygen (O2) loss indicated by the geologic record. The effect of these changes on animal survival is evaluated using the Metabolic Index (), a measure of scope for aerobic activity governed by organismal traits sampled in diverse modern species. Modeled loss of aerobic habitat predicts lower extinction intensity in the tropics, a pattern confirmed with a spatially explicit analysis of the marine fossil record. The combined physiological stresses of ocean warming and O2 loss can account for more than half the magnitude of the "Great Dying."
66 show abstract
2018-12-06T10:38:29-08:00
Studies of the peopling of the Americas have focused on the timing and number of initial migrations. Less attention has been paid to the subsequent spread of people within the Americas. We sequenced 15 ancient human genomes spanning from Alaska to Patagonia; six are ≥10,000 years old (up to ~18x coverage). All are most closely related to Native Americans, including those from an Ancient Beringian individual and two morphologically distinct "Paleoamericans." We found evidence of rapid dispersal and early diversification that included previously unknown groups as people moved south. This resulted in multiple independent, geographically uneven migrations, including one that provides clues of a Late Pleistocene Australasian genetic signal, as well as a later Mesoamerican-related expansion. These led to complex and dynamic population histories from North to South America.
67 show abstract
2018-12-06T10:38:29-08:00
Predicting and managing the global carbon cycle requires scientific understanding of ecosystem processes that control carbon uptake and storage. It is generally assumed that carbon cycling is sufficiently characterized in terms of uptake and exchange between ecosystem plant and soil pools and the atmosphere. We show that animals also play an important role by mediating carbon exchange between ecosystems and the atmosphere, at times turning ecosystem carbon sources into sinks, or vice versa. Animals also move across landscapes, creating a dynamism that shapes landscape-scale variation in carbon exchange and storage. Predicting and measuring carbon cycling under such dynamism is an important scientific challenge. We explain how to link analyses of spatial ecosystem functioning, animal movement, and remote sensing of animal habitats with carbon dynamics across landscapes.
68 show abstract
2018-12-06T10:38:29-08:00
To discover leads for next-generation chemoprotective antimalarial drugs, we tested more than 500,000 compounds for their ability to inhibit liver-stage development of luciferase-expressing Plasmodium spp. parasites (681 compounds showed a half-maximal inhibitory concentration of less than 1 micromolar). Cluster analysis identified potent and previously unreported scaffold families as well as other series previously associated with chemoprophylaxis. Further testing through multiple phenotypic assays that predict stage-specific and multispecies antimalarial activity distinguished compound classes that are likely to provide symptomatic relief by reducing asexual blood-stage parasitemia from those which are likely to only prevent malaria. Target identification by using functional assays, in vitro evolution, or metabolic profiling revealed 58 mitochondrial inhibitors but also many chemotypes possibly with previously unidentified mechanisms of action.

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Journal Citation Reports (2017)

Impact factor: 41.058
Q1 (Multidisciplinary Sciences (2/64))

Scopus Journal Metrics (2017)

SJR: 14.142
SNIP: 7.154
Impact (Scopus CiteScore): 1.585
Quartile: Q1
CiteScore percentile: 99%
CiteScore rank: 1 out of 87
Cited by WUR staff: 6112 times. (2014-2016)

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