Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 301127
Title Short-term fasting does not aggravate immunosuppression in harbour seals (Phoca vitulina) with high body burdens of organochlorines
Author(s) Swart, R.L. de; Ross, P.S.; Timmerman, H.H.; Hijman, W.C.; Ruiter, E. de; Djien Liem, A.K.; Brouwer, A.; Loveren, H. van; Reijnders, P.J.H.; Vos, J.G.; Osterhaus, A.D.M.E.
Source Chemosphere 31 (1995)10. - ISSN 0045-6535 - p. 4289 - 4306.
Department(s) Institute for Forestry and Nature Research
Sub-department of Toxicology
Publication type Refereed Article in a scientific journal
Publication year 1995
Abstract Two groups of 11 harbour seals (Phoca vitulina) with different body burdens of organochlorines were subjected to an experimental 15-day fasting period, during which they lost an average 16.5% of their body weights. Blood levels of the most persistent organochlorines showed an approximate twofold increase, while levels of aryl hydrocarbon receptor-binding organochlorines remained largely unaffected. Few differences in immunological parameters were observed between the two dietary groups. Numbers of circulating lymphocytes dropped to about 65% of the initial values and NK cell activity showed a slight increase in both groups. Mitogen- and antigen-induced lymphoproliferative responses of the Baltic group of seals remained within normal ranges. These results suggest that relatively short-term fasting periods do not present an additional immunotoxicological risk to seals with high body burdens of organochlorines.
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