Cell suspension cultures of Linum album were established, which were able to synthesize and accumulate lignans. Podophyllotoxin and 5-methoxypodophyllotoxin were the main products and were present as glycosides, together with small amounts of deoxypodophyllotoxin, 5′-demethoxy-5-methoxypodophyllotoxin, lariciresinol, pinoresinol, matairesinol, α- and β-peltatin, as well as the monolignol glucoside, coniferin. In dark and light grown cultures, maximal product yields of lignans of up to 0.2% and 0.5% of the dry weight, respectively, were achieved, mainly consisting of podophyllotoxin.
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