ID Lelystad, Institute for Animal Science and Health
The invention relates to the field of eradication or control of viral diseases of animals, more specifically to vaccines used in the eradication or control of pestivirus infections in pigs or ruminants. The invention provides a recombinant nucleic acid derived from a genotype of a pestivirus, and chimeric virus and vaccine derived thereof, wherein a first fragment or part thereof encoding at least one immunodominant part at least partly responsible for providing protection against a wild-type pestivirus infection of a viral protein has been modified to render said immunodominant part incapable of eliciting antibodies specific for said genotype.
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