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Record number 317384
Title Effects of fatty acids on gene expression : role of peroxisome proliferator-activated receptor alpha, liver X receptor alpha and sterol regulatory element-binding protein-1c
Author(s) Kersten, S.
Source Proceedings of the Nutrition Society 61 (2002). - ISSN 0029-6651 - p. 371 - 374.
Department(s) Human Nutrition (HNE)
Publication type Refereed Article in a scientific journal
Publication year 2002
Abstract Dietary fatty acids have numerous effects on cellular function, many of which are achieved by altering the expression of genes. The present paper reviews recent data on the mechanisms by which fatty acids influence DNA transcription, and focus specifically on the importance of three transcription factors: peroxisome proliferator-activated receptor α; liver X receptor α; sterol regulatory element-binding protein 1c. These data indicate that fatty acids induce or inhibit the mRNA expression of a variety of different genes by acting both as agonists and as antagonists for nuclear hormone receptors.
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