Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 318148
Title Identification of o-quinone/quinone methide metabolites of quercetin in a cellular in vitro system
Author(s) Awad, H.M.; Boersma, M.G.; Boeren, S.; Woude, H. van der; Zanden, J. van; Bladeren, P.J. van; Vervoort, J.; Rietjens, I.M.C.M.
Source FEBS Letters 520 (2002)1-3. - ISSN 0014-5793 - p. 30 - 34.
DOI https://doi.org/10.1016/S0014-5793(02)02754-0
Department(s) Biochemistry
Sub-department of Toxicology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2002
Abstract Formation of quercetin quinone/quinone methide metabolites, reflected by formation of the glutathionyl quercetin adducts as authentic metabolites, was investigated in an in vitro cell model (B16F-10 melanoma cells). Results of the present study clearly indicate the formation of glutathionyl quercetin adducts in a tyrosinase-containing melanoma cell line, expected to be representative also for peroxidase-containing mammalian cells and tissues. The data obtained also support that the adducts are formed intracellular and subsequently excreted into the incubation medium and reveal for the first time evidence for the pro-oxidative metabolism of quercetin in a cellular in vitro model.
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