Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 319065
Title Flavoenzyme-catalyzed oxygenations and oxidations of phenolic compounds
Author(s) Moonen, M.J.H.; Fraaije, M.W.; Rietjens, I.M.C.M.; Laane, C.; Berkel, W.J.H. van
Source Advanced Synthesis and Catalysis 344 (2002). - ISSN 1615-4150 - p. 1023 - 1035.
Department(s) Biochemistry
Sub-department of Toxicology
Publication type Refereed Article in a scientific journal
Publication year 2002
Abstract Flavin-dependent monooxygenases and oxidases play an important role in the mineralization of phenolic compounds. Because of their exquisite regioselectivity and stereoselectivity, these enzymes are of interest for the biocatalytic production of fine chemicals and food ingredients. In our group, we have characterized several flavoenzymes that act on phenolic compounds, including 4-hydroxybenzoate 3-hydroxylase, 3-hydroxyphenylacetate 6-hydroxylase, 4-hydroxybenzoate 1-hydroxylase (decarboxylating), hydroquinone hydroxylase, 2-hydroxybiphenyl 3-monooxygenase, phenol hydroxylase, 4-hydroxyacetophenone monooxygenase and vanillyl-alcohol oxidase. The catalytic properties of these enzymes are reviewed here, together with insights obtained from site-directed and random mutagenesis.
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