Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 319401
Title Structures of two major histocompatibility complex class I genes of the rainbow trout (Oncorhynchus mykiss)
Author(s) Shum, B.P.; Mason, P.M.; Magor, K.E.; Flodin, L.R.; Stet, R.J.M.; Parham, P.
Source Immunogenetics 54 (2002). - ISSN 0093-7711 - p. 193 - 199.
DOI http://dx.doi.org/10.1007/s00251-002-0450-z
Department(s) Cell Biology and Immunology
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2002
Abstract Abstract. Here we describe two rainbow trout major histocompatibility complex (MHC) class I genes characterized from 5 phage genomic clones prepared from a single fish. Clone GC71 contains all exons except a leader peptide-encoding exon. An open reading frame is maintained, and thus the gene MhcOnmy-U71 could be expressed in this individual. The class I gene found on clone GC41 lacks exons encoding the leader peptide and cytoplasmic domain. This gene, MhcOnmy-U41p, is a pseudogene due to a deletion in the !2 domain-encoding exon causing premature termination. Both the Onmy-U71 and Onmy-U41p genes are distinguished by long introns between the exons encoding the !1 and !2 domains. Clone GC41 also contains the 3' exons of the LMP7/PSMB8 gene encoding the ânterferon-induced proteosome subunit of rainbow trout.
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