Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 319447
Title Optimal Parametric Sensitivity Control for the Estimation of Kinetic parameters in Bioreactors
Author(s) Keesman, K.J.; Stigter, J.D.
Source Mathematical Biosciences 179 (2002)1. - ISSN 0025-5564 - p. 95 - 111.
DOI https://doi.org/10.1016/S0025-5564(02)00097-4
Department(s) Systems and Control Group
WIMEK
Publication type Refereed Article in a scientific journal
Publication year 2002
Abstract In this paper the well-known problem of optimal input design is considered. In particular, the focus is on input design for the estimation of kinetic parameters in bioreactors. The problem is formulated as follows: given the model structure (f, g), which is assumed to be affine in the input, and the specific parameter of interest θk find a feedback law that maximizes the sensitivity of the model output to the parameter under different flow conditions in the bioreactor and, possibly, minimize the input or state costs. Analytical solutions to these problems are presented. As an example a bioreactor with a biomass that grows according to the well-known Monod kinetics is considered
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