Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 320387
Title Value of alternative sample matrices in residue analysis for stanozolol
Author(s) Nielen, M.W.F.; Hooijerink, H.; Essers, M.L.; Lasaroms, J.J.P.; Bennekom, E.O. van; Brouwer, L.
Source Analytica Chimica Acta 483 (2003)1-2. - ISSN 0003-2670 - p. 11 - 17.
Department(s) RIKILT - Analyse & OntwikkelingBU Microbiological & Chemical Food Analysis
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) anabolic-steroids - doping control - hair
Abstract Detection of hormones and veterinary drugs in urine samples is limited to the short-term following illegal administration. Alternative sample matrices such as hair or retina are of interest for prolonged detectability of residues. In this preliminary study, we developed sensitive liquid chromatography¿tandem mass spectrometry methods for the confirmatory analysis of stanozolol in different matrices and applied them to urine, retina and hair samples obtained from 11 suspect bovines at the slaughterhouse. Most of the stanozolol metabolite (16-hydroxystanozolol) levels in urine samples were below 0.5 ng ml-1, but nevertheless in some urines traces of this metabolite could still be positively confirmed. Retina samples were all negative so the value of this matrix for stanozolol might be questioned. The hair samples, on the other hand, yielded many positive stanozolol results, and in some animals levels were up to 100-fold higher than the corresponding metabolite levels in urine thereby underlining the potential for prolonged detectability of stanozolol abuse.
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