Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 326314
Title Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model
Author(s) Verwei, M.; Arkbåge, K.; Havenaar, R.; Berg, H. van den; Witthöft, C.; Schaafsma, G.
Source The Journal of Nutrition 133 (2003). - ISSN 0022-3166 - p. 2377 - 2383.
Department(s) Chair Nutrition and Health over the Lifecourse
Laboratory of Entomology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) folate-binding-protein - neural-tube defects - red-cell folate - cows milk - plasma homocysteine - small-intestine - dietary-folate - bovine-milk - bioavailability - prevention
Abstract Dairy products are a potential matrix for folate fortification to enhance folate consumption in the Western world. Milk folate-binding proteins (FBP) are especially interesting because they seem to be involved in folate bioavailability. In this study, folate bioaccessibility was investigated using a dynamic computer-controlled gastrointestinal model [TNO gastrointestinal model (TIM)]. We used both ultrahigh temperature (UHT)-processed milk and pasteurized milk, differing in endogenous FBP concentrations and fortified with folic acid or 5-methyltetrahydrofolate (5-CH3-H(4)folate). To study FBP stability during gastrointestinal passage and the effect of additional FBP on folate bioaccessibility, FBP-fortified UHT and pasteurized milk products were also tested. Folate bioaccessibility and FBP stability were measured by taking samples along the compartments of the gastrointestinal model and measuring their folate and FBP concentrations. Folate bioaccessibility from folic acid-fortified milk products without additional FBP was 58-61%. This was lower (P <0.05) than that of the 5-CH3-H(4)folate-fortified milk products (71%). Addition of FBP reduced (P <0.05) folate bioaccessibility from folic acid-fortified milk (44-51%) but not from 5-CH3-H(4)folate-fortified milk products (72%). The residual FBP levels in the folic acid- and 5-CH3-H(4)folate-fortified milk products after gastrointestinal passage were 13-16% and 0-1%, respectively, of the starting amounts subjected to TIM. In conclusion, milk seems to be a suitable carrier for folate, because both folic acid and 5-CH3-H(4)folate are easily released from the matrix and available for absorption. However, our results suggest that folic acid remains partly bound to FBP during passage through the small intestine, which reduces the bioaccessibility of folic acid from milk in this model.
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