Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 334445
Title Fine mapping of quantitative trait loci using linkage disequilibrium in inbred plant populations
Author(s) Bink, M.C.A.M.; Meuwissen, T.H.E.
Source Euphytica 137 (2004)1. - ISSN 0014-2336 - p. 95 - 99.
Department(s) PRI Biometris
Publication type Refereed Article in a scientific journal
Publication year 2004
Abstract Linkage disequilibrium (LD)-based methods capitalize on the number of generations that occurred since the appearance of a mutation at a QTL and can produce extremely accurate estimates of the QTL position. Here, we describe a regression methodology to estimate the effect of marker haplotypes on a quantitative trait for the case of inbred plant populations. The method builds upon probabilities of being 'Identical by Descent' that are obtained via a gene-dropping simulation, where inbreeding is assumed to be due to a single seed descent process. The method was empirically tested via Monte Carlo simulation and results showed that the power to detect the true QTL position depended on the age of the QTL mutation, effective population size and marker distances. Also, increased marker polymorphism dramatically improved power and the method seemed fairly robust to differences in genetic and population assumptions
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