Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 342631
Title Folate and the methylenetetrahydrofolate reductase 677C ---> T mutation correlate with cognitive performance
Author(s) Durga, J.; Boxtel, M.P.J. van; Schouten, E.G.; Bots, M.L.; Kok, F.J.; Verhoef, P.
Source Neurobiology of aging 27 (2006)2. - ISSN 0197-4580 - p. 334 - 343.
Department(s) Chair Nutrition and Health over the Lifecourse
Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) ischemic-heart-disease - alzheimers-disease - risk factor - folic-acid - 10-formyltetrahydrofolate dehydrogenase - mendelian randomization - plasma homocysteine - oxidative stress - elderly patients - common mutation
Abstract Low folate status has been associated with cognitive decline. We investigated the association of folate status and the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C ¿ T polymorphism with performance on a battery of neuropsychological tests. Furthermore, we investigated whether the association of folate with cognitive performance was mediated by plasma homocysteine or risk of vascular disease. We used cross-sectional data from 818 individuals aged 50¿70 years old. Low concentrations of erythrocyte folate but not serum folate were associated with poor performance on complex speed and memory tasks, independent of educational level and conventional risk factors of vascular disease. These associations were not mediated by homocysteine concentrations or carotid intima-media thickness. Subjects with the MTHFR 677TT genotype tended to perform better on cognitive tasks than CC/CT subjects, although this was significant for sensorimotor speed only (differences in Z-scores between MTHFR 677TT homozygotes and CC homozygotes ¿0.15, 95% CI: ¿0.30 to 0.00). Low concentrations of erythrocyte folate are associated with decreased cognitive performance, possibly through a homocysteine-independent mechanism such as DNA infidelity and mitochondrial decay.
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