Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 343237
Title Effects of neonatal amygdala lesions on [I-125] neurotensin binding in specific brain areas of adult rat
Author(s) Bouwmeester, H.; Snapper, J.; Ronken, E.; Kruse, C.G.; Ree, J.M. van
Source European Journal of Neuroscience 17 (2003)6. - ISSN 0953-816X - p. 1319 - 1322.
Department(s) RIKILT - Business Unit Safety & Health
Publication type Refereed Article in a scientific journal
Publication year 2003
Keyword(s) ventral tegmental area - dopamine interactions - receptor antagonist - neurons - sites - immunoreactivity - schizophrenia - 142948a
Abstract Neurotensin has been implicated in the pathophysiology of schizophrenia. The neonatal amygdala lesion in rat has been proposed to be a neurodevelopmental model for some aspects of schizophrenia. [125I] Neurotensin binding was assessed in adult rats using in vitro autoradiography following a lesion of the basolateral amygdala at postnatal day 7 (Pd 7) or postnatal day 21 (Pd 21). The Pd 7 and Pd 21 lesions differentially affected neurotensin receptor densities in the hippocampal complex and (less pronounced) in the dopaminergic cell regions, implying a neurodevelopmental cause. These results may be of relevance for the involvement of neurotensin in the pathogenesis of schizophrenia.
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