Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 343959
Title Increased protection of shrimp against white spot syndrome virus by oral administration of a major envelope protein: is vaccination reality?
Author(s) Witteveldt, J.; Vlak, J.M.; Hulten, M.C.W. van
Event Congres in Nusa Dua, Indonesia, 2005-05-08/2005-05-14
Department(s) Laboratory of Virology
PE&RC
Publication type Abstract in scientific journal or proceedings
Publication year 2005
Abstract Since the 1990s shrimp culture has been hampered by mass mortalities in ponds throughout the world. Penaeid shrimp are affected by many infectious agents, mainly of bacterial and viral origin, and especially by white spot syndrome virus (WSSV). The lattar has had a major impact on shrimp culture since its discovery in 1992 and it is still a major problem. The only measures presently used to control WSSV are rigorous sanitation and adequate health management practices. Alternative intervention strategies such as vaccination should be and are currently being explored. Recent experiments in the shrimp Penaeus monodon revealed that oral administration of the major envelope protein VP28 overexpressed in bacteria results in high protection levels compared to control groups (Fig. 1). Though these results are promising for the further development of a practical disease prevention strategy, the mechanism of the protection is unclear and it is important to understand it from a biological viewpoint. Shrimp and crustaceans in general are thought to lack a speciimmune system and thus to be unable to recognize, let alone respond specito, foreign proteins. Nevertheless, increased protection against disease has been observed by oral administration and intramuscular injection of WSSV structural proteins and this has been called a quasi-immune response. As long as the nature of these observed responses is unknown, we can only speculate on the processes involved. Is it a speciimmune response or is it the result of something different like competition for receptors? Another question is whether the protection is durable. Experiments designed to tackle these questions and answers to them will be discussed.
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