Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 345786
Title Investigating the Permanent Electric Dipole Moment of ß-Lactoglobulin Fibrils, Using Transient Electric Birefringence
Author(s) Rogers, S.S.; Venema, P.; Ploeg, J.P.M. van der; Linden, E. van der; Sagis, L.M.C.; Donald, A.M.
Source Biopolymers 82 (2006)3. - ISSN 0006-3525 - p. 241 - 252.
Department(s) Physics and Physical Chemistry of Foods
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) amyloid fibrils - polyelectrolyte solutions - length distribution - protein - nmr - macromolecules - polarizability - spectroscopy - aggregation - constraints
Abstract Amyloid fibrils, which are polymeric assemblies of protein molecules, have been intensively studied on a structural level, yet due to complications such as the disorder within the molecules, several aspects of their structure remain mysterious. Similarly, the kinetics of assembly are not well understood. Here we investigate the electric dipole moment of ß-lactoglobulin fibrils, a model amyloid fibril system, by applying the technique of transient electric birefringence. This moment appears to be large, and comparable to the total moment of the constituent protein monomers if they were joined in a chain, head-to-tail, without changing conformation, suggesting an ordered joining of monomers in the fibril. Such an ordered assembly may have implications for the assembly mechanism of ß-lactoglobulin fibrils in particular, and amyloid fibrils in general
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