Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 345791
Title Effects of central infusion and immunoneutralization of growth hormone on the timing of puberty and plasma leptin levels in the female rat
Author(s) Zeinoaldini, S.; Swarts, J.J.M.; Heijning, B.J.M. van de
Source Regulatory Peptides 134 (2006)2-3. - ISSN 0167-0115 - p. 158 - 163.
Department(s) Human and Animal Physiology
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) gene-expression - serum leptin - metabolic signal - body-composition - transgenic mice - adipose-tissue - messenger-rna - food-intake - gh gene - insulin
Abstract Growth hormone (GH) levels increase during puberty though its role in puberty onset is still unclear. An interaction is suggested between GH and leptin, as triggering factor of puberty. To evaluate the role of GH on the timing of puberty and its relation with leptin, we centrally administered recombinant human GH (rhGH; 1 ¿g/day) to normally fed or food-restricted (FR) prepubertal female rats, and monitored time of vaginal opening (VO). Median time of VO was equally postponed in FR animals and in normally fed rhGH-infused rats: median time of VO was respectively 35 and 34 vs. 27 d. Central infusion of rhGH in FR rats partially restored the delay in VO. Plasma leptin levels were increased in rhGH-infused animals, normally fed or FR. Centrally infused anti-rat GH (0.6 ¿g/day) did not affect plasma leptin levels, but advanced median time of VO (25 vs. 28 d) in pair-fed female rats but not in ad lib-fed animals. The effects of the centrally infused compounds appear to depend on the dietary regime imposed on the prepubertal animals. Furthermore, plasma leptin levels show no direct or predictive relation to the time of VO. The data indicate an involvement of GH in puberty onset, but do not explain the mechanism employed.
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