Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 345991
Title Adaptation to the cost of resistance: a model of compensation, recombination, and selection in a haploid organism
Author(s) Wijngaarden, P.J.; Bosch, F. van den; Jeger, M.J.; Hoekstra, R.F.
Source Proceedings of the Royal Society. B: Biological Sciences 272 (2005)1558. - ISSN 0962-8452 - p. 85 - 89.
DOI https://doi.org/10.1098/rspb.2004.2910
Department(s) Laboratory of Phytopathology
Laboratory of Genetics
PE&RC
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) antibiotic-resistance - escherichia-coli - biological cost - evolution - populations - fitness - mutations - epistasis - time
Abstract Populations of pathogenic organisms often evolve resistance in response to the use of pesticides or antibiotics. This rise of resistance may be followed by a fall when chemical control is suspended and resistance alleles carry a fitness cost. Another possibility is that mutations at secondary loci compensate for the cost, usually without loss of resistance. This enables resistant types to withstand invasion by the susceptible wild-type; resistance then persists in the population, which reduces the efficacy of future pesticide or antibiotic use. We examined a two-locus model of a haploid organism that adapts to the cost of resistance by a single compensatory mutation. We addressed the question how different combinations of cost and compensation and different levels of recombination affect the consequences of a single pesticide application. Resistance will become fixed in the population when the fraction of the population exposed to pesticide exceeds the cost of resistance. Compensatory mutations reduce the cost of resistance and therefore this threshold level of pesticide use. In the absence of pesticide, recombination promotes stability of equilibria. In the presence of pesticide, recombination accelerates the fixation of resistance and compensating alleles; recombination may also enable the persistence of compensated resistant types after pesticide use
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