Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 345992
Title Limits to adaptation in asexual populations
Author(s) Visser, J.A.G.M. de; Rozen, D.
Source Journal of Evolutionary Biology 18 (2005)4. - ISSN 1010-061X - p. 779 - 788.
DOI https://doi.org/10.1111/j.1420-9101.2005.00879.x
Department(s) Laboratory of Genetics
PE&RC
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) term experimental evolution - escherichia-coli - rna virus - beneficial mutations - bacterial-populations - mullers ratchet - mutator genes - fitness - dynamics - meltdown
Abstract In asexual populations, the rate of adaptation is basically limited by the frequency and properties of spontaneous beneficial mutations. Hence, knowledge of these mutational properties and how they are affected by particular evolutionary conditions is a precondition for understanding the process of adaptation. Here, we address how the rate of adaptation of asexual populations is limited by its population size and mutation rate, as well as by two factors affecting the fraction of mutations that confer a benefit, i.e. the initial adaptedness of the population and the variability of the environment. These factors both influence which mutations are likely to occur, as well as the probability that they will ultimately contribute to adaptation. We attempt to separate the consequences of these basic population features in terms of their effect on the rate of adaptation by using results from evolution experiments with microorganisms
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