Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 346437
Title Effects of gastric emptying on the postprandial ghrelin response
Author(s) Blom, W.A.M.; Lluch, A.; Vinoy, S.; Stafleu, A.; Berg, R. van den; Holst, J.J.; Kok, F.J.; Hendriks, H.F.J.
Source American Journal of Physiology. Endocrinology and Metabolism 290 (2006)2. - ISSN 0193-1849 - p. E389 - E395.
Department(s) Chair Nutrition and Health over the Lifecourse
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) glucagon-like peptide-1 - acylated ghrelin - food-intake - inhibitory polypeptide - paracetamol absorption - nonacylated ghrelin - circulating ghrelin - insulin - humans - secretion
Abstract Distension and chemosensitization of the stomach are insufficient to induce a ghrelin response, suggesting that postgastric feedback is required. This postgastric feedback may be regulated through insulin. We investigated the relation between gastric emptying rate and the postprandial ghrelin response as well as the role of insulin and other hormones possibly mediating this response. Fifteen healthy men [BMI 21.6 kg/m2 (SD 1.9), age 20.5 yr (SD 2.5)] were studied in a single-blind, crossover design. Subjects received two treatments separated by 1 wk: 1) a dairy breakfast in combination with a 3-h intravenous infusion of glucagon-like peptide-1 (GLP-1), which delays gastric emptying, and 2) a dairy breakfast in combination with a 3-h intravenous infusion of saline. Blood samples were drawn before breakfast and during the infusion. Postprandial ghrelin (total) responses were lower following the saline infusion compared with the GLP-1 infusion (P <0.05). Acetaminophen concentrations, an indirect measurement of gastric emptying rate, were inversely correlated with total ghrelin concentrations (saline r = ¿0.76; 95% CI = ¿0.90, ¿0.49, GLP-1 r = ¿0.47; 95% CI = ¿0.76, ¿0.04). Ghrelin concentrations were only weakly correlated with insulin concentrations (saline r = ¿0.36; 95% CI = ¿0.69, 0.09; GLP- 1 r = ¿0.42; 95% CI = ¿0.73, 0.03), but strongly inversely correlated with GIP concentrations (saline r = ¿0.74; 95% CI= ¿0.89, ¿0.45; GLP-1 r = ¿0.63; 95% CI = ¿0.84, ¿0.27). In conclusion, our results support the hypothesis that ghrelin requires postgastric feedback, which may not be regulated through insulin. Conversely, our data suggest a role of glucose-dependent insulinotropic polypeptide in ghrelin secretion
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