Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 347520
Title Differential induction of electrophile-responsive element-regulated genes by n-3 and n-6 polyunsaturated fatty acids
Author(s) Beelen, V.A. van; Aarts, M.G.M.; Reus, A.; Mooibroek, H.; Sijtsma, L.; Bosch, H.J.; Rietjens, I.M.C.M.; Alink, G.M.
Source FEBS Letters 580 (2006)19. - ISSN 0014-5793 - p. 4587 - 4590.
DOI https://doi.org/10.1016/j.febslet.2006.07.028
Department(s) AFSG Biobased Products
Laboratory of Genetics
PRI Bioscience
Sub-department of Toxicology
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) antioxidant response - fish-oil - dietary - carcinogenesis - mechanisms - protection - oxidation - reductase - pathway - cancer
Abstract In this study the n-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid and docosahexaenoic acid appear to be effective inducers of electrophile-responsive element (EpRE) regulated genes, whereas the n-6 PUFA arachidonic acid is not. These n-3 PUFAs need to be oxidized to induce EpRE-regulated gene expression, as the antioxidant vitamin E can partially inhibit the PUFA induced dose-dependent effect. Results were obtained using a reporter gene assay, real-time RT-PCR and enzyme activity assays. The induction of EpRE-regulated phase II genes by n-3 PUFAs may be a major pathway by which n-3 PUFAs, in contrast to n-6 PUFAs, are chemopreventive and anticarcinogenic.
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