Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 348022
Title Bioavailability of folic acid from fortified pasteurised and UHT-treated milk in humans
Author(s) Jong, R.J.; Verwei, M.; West, C.E.; Vliet, T. van; Siebelink, E.; Berg, H. van den; Castenmiller, J.J.M.
Source European Journal of Clinical Nutrition 59 (2005)8. - ISSN 0954-3007 - p. 906 - 913.
DOI https://doi.org/10.1038/sj.ejcn.1602159
Department(s) Chair Nutrition and Health over the Lifecourse
Chair Nutrition and Disease
Chair Nutrition Metabolism and Genomics
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) folate-binding-protein - plasma homocysteine concentrations - neural-tube defects - methylenetetrahydrofolate reductase - food fortification - vascular-disease - common mutation - dietary-folate - risk factor - cows milk
Abstract Objective The aim of this study was to investigate whether milk fortified with folic acid enhances the folate status of humans and whether the presence of folate-binding proteins (FBP) in pasteurised milk affects the bioavailability of folic acid from fortified milk. In untreated and pasteurised milk, folate occurs bound to FBP, while FBP is (partly) denatured in ultra-high-temperature (UHT)-treated milk. The effect of FBP on folate bioavailability is still unclear. Design, subjects and setting Healthy, free-living subjects (n=69) aged 18-49 y participated in a 4-week double-blind, placebo-controlled dietary intervention study. Intervention In addition to a fully controlled diet, the subjects consumed each day 500 ml of pasteurised or UHT milk, either fortified or not with 200 g folic acid. Results Consumption of fortified milk increased folate concentrations in serum and in red blood cells (RBC) by 6.6-7.0 nmol/l (P
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