Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 351534
Title Disease induction by human microbial pathogens in plant-model systems: potential, problems and prospects
Author(s) Baarlen, P. van; Belkum, A. van; Thomma, B.P.H.J.
Source Drug Discovery Today 12 (2007)3/4. - ISSN 1359-6446 - p. 167 - 173.
Department(s) Laboratory of Phytopathology
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) programmed cell-death - pseudomonas-aeruginosa - arabidopsis-thaliana - staphylococcus-aureus - virulence factors - salicylic-acid - aal-toxin - secondary metabolites - acetylsalicylic-acid - signaling pathways
Abstract Relatively simple eukaryotic model organisms such as the genetic model weed plant Arabidopsis thaliana possess an innate immune system that shares important similarities with its mammalian counterpart. In fact, some human pathogens infect Arabidopsis and cause overt disease with human symptomology. In such cases, decisive elements of the plant's immune system are likely to be targeted by the same microbial factors that are necessary for causing disease in humans. These similarities can be exploited to identify elementary microbial pathogenicity factors and their corresponding targets in a green host. This circumvents important cost aspects that often frustrate studies in humans or animal models and, in addition, results in facile ethical clearance
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