Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 351554
Title Functional genomics of the thermo-acidophilic archaeon Sulfolobus solfataricus
Author(s) Oost, J. van der; Walther, J.; Brouns, S.J.J.; Werken, H.J.G. van de; Snijders, A.P.L.; Wright, P.C.; Andersson, A.; Bernander, R.; Vos, W.M. de
Source In: Extremophiles / Rainey, F.A., Oren, A., New york : Elsevier (Methods in Microbiology ) - ISBN 9780125215367 - p. 201 - 231.
Department(s) Microbiological Laboratory
Publication type Peer reviewed book chapter
Publication year 2006
Keyword(s) 2-dimensional gel-electrophoresis - cdna microarray experiments - upper temperature limit - hyperthermophilic archaeon - methanococcus-jannaschii - pyrococcus-furiosus - mass-spectrometry - gene-expression - shotgun proteomics - sequence
Abstract Archaea and bacteria that optimally grow at temperatures above 60C and 80C are referred to as thermophiles and hyperthermophiles, respectively (Stetter, 1996). Since their discovery in the late 1960s (Brock and Freeze, 1969), attempts were made to reveal the secrets of the thermal resistance of these microorganisms, initially by physiological, biochemical and genetic analysis (Allers and Mevarech, 2005). In addition, the sequencing of the genomes of many thermophiles during the last decade has allowed for a series of genome-based research lines. Comparative genomics is the in silico analysis of genome data that aims to predict the metabolic potential of an organism, including the interconversions of metabolites and the regulation thereof (Ettema et al., 2005; Makarova and Koonin, 2003). Functional genomics is the experimental analysis at the level of RNA (transcriptomics), protein (proteomics), as well as metabolites (metabolomics). In general, such holistic studies aim at addressing the phenotypic response of an organism either to different cultivation conditions, or to genotypic variations. Here we review recent developments of functional genomics of thermophiles in general, and of the thermo-acidophilic archaeon Sulfolobus solfataricus in particular.
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