Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 351668
Title Intakes of 4 dietary lignans and cause-specific and all-cause mortality in the Zutphen elderly study
Author(s) Milder, I.E.J.; Feskens, E.J.M.; Arts, I.C.W.; Bueno-de Mesquita, H.B.; Hollman, P.C.H.; Kromhout, D.
Source American Journal of Clinical Nutrition 84 (2006)2. - ISSN 0002-9165 - p. 400 - 405.
Department(s) Chair Nutrition and Disease
Chair Nutrition and Health over the Lifecourse
RIKILT - Business Unit Safety & Health
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) breast-cancer risk - ischemic-heart-disease - plant lignans - phytoestrogen intake - mammalian lignans - postmenopausal women - serum concentrations - enterolactone - secoisolariciresinol - lariciresinol
Abstract Plant lignans are converted to enterolignans that have antioxidant and weak estrogen-like activities, and therefore they may lower cardiovascular disease and cancer risks. OBJECTIVE: We investigated whether the intakes of 4 plant lignans (lariciresinol, pinoresinol, secoisolariciresinol, and matairesinol) were inversely associated with coronary heart disease (CHD), cardiovascular diseases (CVD), cancer, and all-cause mortality. DESIGN: The Zutphen Elderly Study is a prospective cohort study in which 570 men aged 64-84 y were followed for 15 y. We recently developed a database and used it to estimate the dietary intakes of 4 plant lignans. Lignan intake was related to mortality with the use of Cox proportional hazards analysis. RESULTS: The median total lignan intake in 1985 was 977 microg/d. Tea, vegetables, bread, coffee, fruit, and wine were the major sources of lignan. The total lignan intake was not related to mortality. However, the intake of matairesinol was inversely associated with CHD, CVD, and all-cause mortality (P
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