Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 352574
Title Effect of increase vegetable and fruit consumption on plasma folate and homocysteine concentrations
Author(s) Bogers, R.P.; Dagnelie, P.C.; Bast, A.; Leeuwen, M. van; Klaveren, J.D. van; Brandt, P.A. van den
Source Nutrition 23 (2007)2. - ISSN 0899-9007 - p. 97 - 102.
DOI http://dx.doi.org/10.1016/j.nut.2006.11.002
Department(s) RIKILT - Business Unit Safety & Health
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) folic-acid - controlled-trial - dietary-folate - heart-disease - metaanalysis - humans - bioavailability - questionnaire - carotenoids - validity
Abstract OBJECTIVE: We assessed the effects of an intervention aimed at increasing the consumption of fruits and vegetables on plasma folate and homocysteine concentrations. METHODS: Seventy-one healthy non-smoking women (mean +/- SD 41 +/- 4 y of age) were randomized to an intervention or a control group. Participants in the intervention group (n = 36) received weekly packets containing fruits and vegetables free of charge and were asked to consume a daily amount of >/=200 g of vegetables and two pieces of fruit (the Dutch recommended intake level) over a period of 1 mo. Control subjects did not receive any intervention. RESULTS: Compared with the control group, reported fruit and vegetable intakes in the intervention group increased by 133 g/d (95% confidence interval [CI] 87-179, P <0.001) for fruits and juice and 64 g/d (95% CI 37-91, P <0.001) for vegetables and estimated folate intake from fruits and vegetables increased by 40 mug/d (95% CI 22-58, P <0.001). However, no effect was observed on plasma folate concentrations (intervention effect 0.3 nmol/L, 95% CI -1.8 to 2.8, P = 0.77) or homocysteine concentrations (intervention effect 0.26 mumol/L, 95% CI -0.34 to 0.87, P = 0.39). CONCLUSION: The results suggest that 4 wk of increased fruit and vegetable consumption to the recommended amounts may be insufficient to change plasma folate and homocysteine concentrations.
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