Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 352725
Title Spatial discrimination deficits by excitotoxic lesions in the MORRIS WATER ESCAPE TASK
Author(s) Spowart-Manning, L.; Staay, F.J. van der
Source Behavioural Brain Research 156 (2005)2. - ISSN 0166-4328 - p. 269 - 279.
DOI http://dx.doi.org/10.1016/j.bbr.2004.05.031
Department(s) Livestock Research
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) entorhinal cortex lesions - scopolamine-induced deficits - alzheimers-disease patients - hippocampal-formation - cholinergic system - memory impairment - rats - metrifonate - maze - behavior
Abstract The effects of the cholinesterase inhibitors (ChEI) metrifonate and donepezil were assessed on spatial performance of rats with bilateral lesions of the entorhinal cortex (EC), which is thought to model early changes in the brains of patients suffering from Alzheimer's disease. In the present study, we found that spatial discrimination deficits in rats, induced by bilateral ibotenic acid (IBO) lesions of the EC region can partially be antagonised by treatment with the cholinesterase inhibitors metrifonate (30 mg kg-1) and donepezil (0.3 and 3 mg kg-1). Performance was improved in the spatial discrimination task compared with that of the EC-lesioned control group. It is concluded that the rat with bilateral EC lesions is a suitable deficit model for the assessment of effects of putative Alzheimer therapeutics
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