Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 35318
Title Vitamin A status affects the efficacy of iron repletion in rats with mild iron deficiency.
Author(s) Roodenburg, A.J.C.; West, C.E.; Beynen, A.C.
Source Journal of Nutritional Biochemistry 7 (1996)2. - ISSN 0955-2863 - p. 99 - 105.
Department(s) Human Nutrition (HNE)
Publication type Refereed Article in a scientific journal
Publication year 1996
Abstract In populations with vitamin A deficiency, vitamin A administration in addition to supplemental iron has been shown to further improve blood indicators of iron status. To obtain clues to associated changes at the level of organ indicators of iron status, we have attempted to mimic previous human studies in a rat model. The influence of vitamin A on selected indices of iron metabolism was studied during iron repletion of rats with mild iron deficiency combined with either vitamin A deficiency or normal vitamin A status. In the vitamin A-deficient rats, but not in those with normal vitamin A status, the administration of vitamin A raised body weight and liver weight. Vitamin A administration also raised the total iron-binding capacity and plasma iron concentrations but depressed iron concentrations in liver, kidney, spleen, and bone in the vitamin A-deficient rats. We conclude that vitamin A administration to rats with both vitamin A and iron deficiency enhances the utilization of iron.
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