Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 353318
Title Genetically-modified mosquitoes for malaria control: requirements to be considered before field releases
Author(s) Touré, Y.T.; Knols, B.G.J.
Source In: Genetically Modified Mosquitoes for Malaria Control / Boëte, Chr., Austin : Landes Bioscience - ISBN 1587060965 - p. 146 - 151.
Department(s) Laboratory of Entomology
Publication type Chapter in scientific book
Publication year 2006
Abstract The technical feasibility of the development of transgenic mosquitoes highly refractory to (rodent) malaria parasites has been demonstrated in the laboratory. Following this proof of principle, genetic control of vectors could have an important role to play in the interruption of transmission of human malarias, if the main developmental and implementation challenges are adequately addressed. These include the establishment of a proof of efficacy and safety for humans and the environment in carefully controlled and contained environments. Prior approval by authorized biosafety, regulatory, and ethical review bodies needs to be obtained before experimental releases. In addition, there is the need to ensure the public and the media that this process is desirable, feasible and can be accomplished safely. Moreover, an appropriate implementation and capacity building plan would increase the chances of making this approach a control method applicable for public health purposes. Analysis of current and anticipated future views of a variety of critical stakeholders enables the provision of a framework that facilitates the transition of research findings from the laboratory to the field. A coordinating mechanism to closely monitor and guide this transition process will be instrumental in furthering developments to fully evaluate the public health potential of this approach.
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