Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 354408
Title Role of genomic typing in taxonomy, evolutionary genetics, and microbial epidemiology.
Author(s) Belkum, A. van; Struelens, M.; Visser, J.A.G.M. de; Verburgh, H.; Tibayrenc., M.
Source Clinical Microbiology Reviews 14 (2001)3. - ISSN 0893-8512 - p. 547 - 560.
DOI http://dx.doi.org/10.1128/CMR.14.3.547-560.2001
Department(s) Laboratory of Genetics
VLAG
PE&RC
Publication type Refereed Article in a scientific journal
Publication year 2001
Keyword(s) resistant staphylococcus-aureus - field gel-electrophoresis - escherichia-coli k-12 - commercial software packages - term experimental evolution - adaptive evolution - molecular evolution - hemorrhagic colitis - infectious-disease - mycobacterium-tuberculosis
Abstract Currently, genetic typing of microorganisms is widely used in several major fields of microbiological research. Taxonomy, research aimed at elucidation of evolutionary dynamics or phylogenetic relationships, population genetics of microorganisms, and microbial epidemiology all rely on genetic typing data for discrimination between genotypes. Apart from being an essential component of these fundamental sciences, microbial typing clearly affects several areas of applied microbiogical research. The epidemiological investigation of outbreaks of infectious diseases and the measurement of genetic diversity in relation to relevant biological properties such as pathogenicity, drug resistance, and biodegradation capacities are obvious examples. The diversity among nucleic acid molecules provides the basic information for all fields described above. However, researchers in various disciplines tend to use different vocabularies, a wide variety of different experimental methods to monitor genetic variation, and sometimes widely differing modes of data processing and interpretation. The aim of the present review is to summarize the technological and fundamental concepts used in microbial taxonomy, evolutionary genetics, and epidemiology. Information on the nomenclature used in the different fields of research is provided, descriptions of the diverse genetic typing procedures are presented, and examples of both conceptual and technological research developments for Escherichia coli are included. Recommendations for unification of the different fields through standardization of laboratory techniques are made
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