Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 355237
Title Determination of the brominated flame retardant, hexabroomcyclodocane in sediments and biota by liquid chromatography-electrospray ionization mass spectrometry
Author(s) Morris, S.; Bersuder, P.; Allchin, C.R.; Zegers, B.; Boon, J.P.; Leonards, P.E.G.; Boer, J. de
Source TrAC : Trends in Analytical Chemistry 25 (2006)4. - ISSN 0165-9936 - p. 343 - 349.
Department(s) RIVO Milieu en Voedselveiligheid
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) diphenylethers
Abstract A method involving reversed-phase, liquid chromatography coupled to electrospray ionisation mass spectrometry (LC-ESI-MS) was developed for separation, detection and quantitation of the alpha-, beta- and gamma-diastereoisomers of hexabromocyclododecane (HBCD). To address the lack of environmental data of this high-production-volume chemical, and to begin to understand the behaviour, the fate and the effects of these stereoisomers, a diastereoisomer-specific method is necessary. Currently, HBCD stereomeric separation is not possible using gas chromatography; thermally-induced rearrangements as well as decomposition of the compound occur at temperatures > 240 degrees C by the initial elimination of hydrogen bromide. The extraction of HBCDs, and subsequent clean-up procedures are similar to those used for polybrominated diphenylethers, and include Soxhlet, homogenisation, mechanical shaking, sulphuric acid treatment and gel-permeation chromatography. Single-quadrupole and ion-trap mass analysers as well as LC separations were optimised using pure and individual HBCD stereoisomers, and determinations were performed using selected ion monitoring (m/z 640.7) of the [M-H](-) ion. This article presents options for analyte extraction and information regarding instrument optimisation, and demonstrates that LC-MS is a suitable technique for quantifying HBCD stereoisomers in complex environmental matrices. Crown Copyright (c) 2005 Published by Elsevier Ltd. All rights reserved.
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