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Record number 355237
Title Determination of the brominated flame retardant, hexabroomcyclodocane in sediments and biota by liquid chromatography-electrospray ionization mass spectrometry
Author(s) Morris, S.; Bersuder, P.; Allchin, C.R.; Zegers, B.; Boon, J.P.; Leonards, P.E.G.; Boer, J. de
Source TrAC : Trends in Analytical Chemistry 25 (2006)4. - ISSN 0165-9936 - p. 343 - 349.
Department(s) RIVO Milieu en Voedselveiligheid
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) diphenylethers
Abstract A method involving reversed-phase, liquid chromatography coupled to electrospray ionisation mass spectrometry (LC-ESI-MS) was developed for separation, detection and quantitation of the alpha-, beta- and gamma-diastereoisomers of hexabromocyclododecane (HBCD). To address the lack of environmental data of this high-production-volume chemical, and to begin to understand the behaviour, the fate and the effects of these stereoisomers, a diastereoisomer-specific method is necessary. Currently, HBCD stereomeric separation is not possible using gas chromatography; thermally-induced rearrangements as well as decomposition of the compound occur at temperatures > 240 degrees C by the initial elimination of hydrogen bromide. The extraction of HBCDs, and subsequent clean-up procedures are similar to those used for polybrominated diphenylethers, and include Soxhlet, homogenisation, mechanical shaking, sulphuric acid treatment and gel-permeation chromatography. Single-quadrupole and ion-trap mass analysers as well as LC separations were optimised using pure and individual HBCD stereoisomers, and determinations were performed using selected ion monitoring (m/z 640.7) of the [M-H](-) ion. This article presents options for analyte extraction and information regarding instrument optimisation, and demonstrates that LC-MS is a suitable technique for quantifying HBCD stereoisomers in complex environmental matrices. Crown Copyright (c) 2005 Published by Elsevier Ltd. All rights reserved.
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