Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 355516
Title Metabolic Flux Analysis of Mammalian Cells
Author(s) Martens, D.E.
Source In: Systems Biology / Al-Rubeai, M., Fussenegger, M., - p. 275 - 300.
Department(s) Bioprocess Engineering
Publication type Peer reviewed book chapter
Publication year 2006
Abstract Metabolic flux analysis has become a standard tool for analyzing metabolism and optimizing bioprocesses. Metabolic flux analysis makes use of a metabolic reaction network in combination with extra-cellular measurements and mass balancing to calculate flux distributions in metabolism. It is a useful tool to analyze metabolism of cells and can be used to optimize the bioprocess in terms of medium design and metabolic engineering of the cells. In this chapter first the fundamental aspects of metabolic networks and the mathematical methods are described. Next a metabolic model for mammalian cells is discussed, Finally, applications of metabolic flux balancing are reviewed. Further extension of the metabolic network models, possibly towards genome-scale models, will further increase the value of these models
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