Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 358984
Title Therapeutic potential of antifungal plant and insect defensins
Author(s) Thevissen, K.; Kristensen, H.H.; Thomma, B.P.H.J.; Cammue, B.P.A.; François, I.E.J.A.
Source Drug Discovery Today 12 (2007)21/22. - ISSN 1359-6446 - p. 966 - 971.
Department(s) Laboratory of Phytopathology
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) dahlia dahlia-merckii - cationic antimicrobial peptides - saccharomyces-cerevisiae - arabidopsis-thaliana - escherichia-coli - drug development - innate immunity - binding-sites - seeds - glucosylceramide
Abstract To defend themselves against invading fungal pathogens, plants and insects largely depend on the production of a wide array of antifungal molecules, including antimicrobial peptides such as defensins. Interestingly, plant and insect defensins display antimicrobial activity not only against plant and insect pathogens but also against human fungal pathogens, including Candida spp. and Aspergillus spp. This review focuses on these defensins as novel leads for antifungal therapeutics. Their mode of action, involving interaction with fungus-specific sphingolipids, and heterologous expression, required for cost-effective production, are major assets for development of plant and insect defensins as antifungal leads. Studies evaluating their in vivo antifungal efficacy demonstrate their therapeutic potential.
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