Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 359976
Title Dietary modulation and structure prediction of rat mucosal pentraxin (Mptx) protein and loss of function in humans
Author(s) Meer, C. van der; Siezen, R.; Kramer, E.H.M.; Reinders, M.; Blokzijl, H.; Meer, R. van der; Keijer, J.
Source Genes & Nutrition 2 (2007)3. - ISSN 1555-8932 - p. 275 - 285.
Department(s) RIKILT - Business Unit Safety & Health
Human and Animal Physiology
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) c-reactive protein - amyloid-p component - gamma-lactone oxidase - colon-cancer - red meat - apoptotic cells - gene-expression - ascorbic-acid - heme - sequence
Abstract Mucosal pentraxin (Mptx), identified in rats, is a short pentraxin of unknown function. Other subfamily members are Serum amyloid P component (SAP), C-reactive protein (CRP) and Jeltraxin. Rat Mptx mRNA is predominantly expressed in colon and in vivo is strongly (30-fold) regulated by dietary heme and calcium, modulators of colon cancer risk. This renders Mptx a potential nutrient sensitive biomarker of gut health. To support a role as biomarker, we examined whether the pentraxin protein structure is conserved, whether Mptx protein is nutrient-sensitively expressed and whether Mptx is expressed in mouse and human. Sequence comparison and 3D modelling showed that rat Mptx is highly homologous to the other pentraxins. The calcium-binding site and subunit interaction sites are highly conserved, while a loop deletion and charged residues contribute to a distinctive ¿top¿ face of the pentamer. In accordance with mRNA expression, Mptx protein is strongly down-regulated in rat colon mucosa in response to high dietary heme intake. Mptx mRNA is expressed in rat and mouse colon, but not in human colon. A stop codon at the beginning of human exon two indicates loss of function, which may be related to differences in intestinal cell turnover between man and rodents
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