Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 360601
Title Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase1, and colorectal adenoma risk: A Dutch case-control study
Author(s) Donk, M. van den; Visker, M.H.P.W.; Harryvan, J.L.; Kok, F.J.; Kampman, E.
Source Cancer Letters 250 (2007)1. - ISSN 0304-3835 - p. 146 - 153.
Department(s) Chair Nutrition and Disease
Human Nutrition (HNE)
Chair Nutrition and Health over the Lifecourse
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) promoter enhancer region - plasma folate - cancer - gene - metabolism - methionine - genotype
Abstract Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism. In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins. The polymorphisms were not associated with adenomas, but there was a borderline significant interaction between TS genotype and vitamin B6: the association between vitamin B6 and adenomas seemed positive in TS 3R/3R individuals, but inverse in TS 2R/2R individuals. This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence. Future research has to indicate whether the TS-B6 interplay is a real effect or a chance finding.
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