Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 360689
Title DGAT1 underlies large genetic variation in milk-fat composition of dairy cows
Author(s) Schennink, A.; Stoop, W.M.; Visker, M.H.P.W.; Heck, J.M.L.; Bovenhuis, H.; Poel, J.J. van der; Valenberg, H.J.F. van; Arendonk, J.A.M. van
Source Animal Genetics 38 (2007)5. - ISSN 0268-9146 - p. 467 - 473.
DOI https://doi.org/10.1111/j.1365-2052.2007.01635.x
Department(s) Animal Breeding and Genetics
Product Design and Quality Management Group
VLAG
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) dierveredeling - melkkoeien - melkvee - zwartbont - melksamenstelling - melkvet - vetzuren - lactatie - genetische variatie - genotypen - genetische parameters - heritability - selectief fokken - nederland - animal breeding - dairy cows - dairy cattle - holstein-friesian - milk composition - milk fat - fatty acids - lactation - genetic variation - genotypes - genetic parameters - selective breeding - netherlands - coa-diacylglycerol acyltransferase - serum-cholesterol - production traits - dietary-fat - bovine - acids - cattle - yield - parameters - disease
Categories Animal Breeding and Genetics (General) / Cattle
Abstract Dietary fat may play a role in the aetiology of many chronic diseases. Milk and milk-derived foods contribute substantially to dietary fat, but have a fat composition that is not optimal for human health. We measured the fat composition of milk samples in 1918 Dutch Holstein Friesian cows in their first lactation and estimated genetic parameters for fatty acids. Substantial genetic variation in milk-fat composition was found: heritabilities were high for short- and medium-chain fatty acids (C4:0¿C16:0) and moderate for long-chain fatty acids (saturated and unsaturated C18). We genotyped 1762 cows for the DGAT1 K232A polymorphism, which is known to affect milk-fat percentage, to study the effect of the polymorphism on milk-fat composition. We found that the DGAT1 K232A polymorphism has a clear influence on milk-fat composition. The DGAT1 allele that encodes lysine (K) at position 232 (232K) is associated with more saturated fat; a larger fraction of C16:0; and smaller fractions of C14:0, unsaturated C18 and conjugated linoleic acid (P <0.001). We conclude that selective breeding can make a significant contribution to change the fat composition of cow¿s milk.
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