Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 360725
Title Genetic resources, genome mapping and evolutionary genomics of the pig (Sus scrofa)
Author(s) Chen, K.; Baxter, T.; Muir, W.M.; Groenen, M.A.M.; Schook, L.B.
Source International Journal of Biological Sciences 3 (2007)3. - ISSN 1449-2288 - p. 153 - 165.
Department(s) Sub-department of Soil Quality
Animal Breeding and Genetics
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) mitochondrial-dna sequence - increased ovulation rate - radiation hybrid panel - pre-messenger-rna - microsatellite markers - natural-selection - phylogenetic-relationships - chromosome evolution - haplotype structure - mammalian genomes
Abstract The pig, a representative of the artiodactyla clade, is one of the first animals domesticated, and has become an important agriculture animal as one of the major human nutritional sources of animal based protein. The pig is also a valuable biomedical model organism for human health. The pig's importance to human health and nutrition is reflected in the decision to sequence its genome (3X). As an animal species with its wild ancestors present in the world, the pig provides a unique opportunity for tracing mammalian evolutionary history and defining signatures of selection resulting from both domestication and natural selection. Completion of the pig genome sequencing project will have significant impacts on both agriculture and human health. Following the pig whole genome sequence drafts, along with large-scale polymorphism data, it will be possible to conduct genome sweeps using association mapping, and identify signatures of selection. Here, we provide a description of the pig genome sequencing project and perspectives on utilizing genomic technologies to exploit pig genome evolution and the molecular basis for phenotypic traits for improving pig production and health.
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