Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 360884
Title Stimulation of pneumovirus-specific CD8(+) T-cells using a non-toxic recombinant ricin delivery system
Author(s) Grimaldi, E.; Claassen, E.A.W.
Source Molecular Immunology 44 (2007)5. - ISSN 0161-5890 - p. 993 - 998.
DOI https://doi.org/10.1016/j.molimm.2006.03.008
Department(s) ASG Infectieziekten
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) respiratory syncytial virus - pneumonia virus - class-i - mice - infection - pathogenesis - vaccines - peptide
Abstract Internalisation of the plant toxin ricin occurs by retrograde transport which delivers the toxin to the ER where it intersects with the MHC class I system for peptide antigen display. Here, we describe the generation of an inactivated, non-toxic, ricin molecule fused to a peptide which elicits a CD8+ T-cell response in mice directed against pneumonia virus of mice, a pneumovirus related to human respiratory syncytial virus. The ricin fusion elicited a significant T-cell response when delivered by intraperitoneal inoculation in the absence of adjuvent. Challenge experiments showed that the T-cell response resulting from inoculation with the ricin-peptide fusion molecule delayed the onset of virus-induced disease.
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