Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 361010
Title Selection for scrapie resistance and simultaneous restriction of inbreeding in the rare sheep breed "Mergellander"
Author(s) Windig, J.J.; Meuleman, H.; Lansbergen, L.M.T.E.
Source Preventive Veterinary Medicine 78 (2007)2. - ISSN 0167-5877 - p. 161 - 171.
Department(s) Livestock Research
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) dierveredeling - schapen - zeldzame rassen - schapenrassen - ooien - rammen - ziekteresistentie - ziektebestrijding - inteelt - inteeltdepressie - ziektepreventie - veredelingsprogramma's - scrapie - scrapieverwekker - allelen - mergellandschaap - animal breeding - sheep - rare breeds - sheep breeds - ewes - rams - disease resistance - disease control - inbreeding - inbreeding depression - disease prevention - breeding programmes - scrapie agent - alleles - mergelland sheep - prp genotype frequencies - natural scrapie - association - gene - populations - codon-136 - survival
Categories Animal Breeding and Genetics (General) / Small Ruminants (Sheep and Goats) / Animal Disease Prevention
Abstract Scrapie is a fatal infectious neurodegenerative disease for which susceptibility is associated with polymorphisms in the ovine prion protein (PrP) gene. Scrapie-eradication programmes are based on eliminating the susceptible VRQ allele and/or breeding for the resistant ARR allele. In rare breeds or breeds with a low frequency of the ARR allele this can lead to unacceptably high inbreeding rates with associated increased risk of genetic defects and inbreeding depression. The conservation status of populations with inbreeding rates (¿F) above 1% is considered critical. In the Dutch rare sheep breed the Mergellander animals carrying ARR alleles are closely related to one another, and could reach 1.53% when only ARR/ARR animals are used as parents. Inbreeding rates can be reduced by selecting the set of parents according to their average co-ancestry. We minimised inbreeding rates by calculating the optimal contribution of each ram and selection of ewes. This resulted in inbreeding rates of ¿0.17% with exclusive use of homozygous ARR rams, and ¿0.38% if use of heterozygous rams was allowed as well. Thus sophisticated breeding programs can prevent unacceptably high inbreeding rates when breeding for scrapie resistance.
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