Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 361595
Title Heterologous protein production in the yeast Kluyveromyces lactis
Author(s) Ooyen, A.J.J. van; Dekker, P.; Huang, M.; Olsthoorn, M.M.A.; Jacobs, D.I.; Colussi, P.A.; Taron, C.H.
Source FEMS Yeast Research 6 (2006)3. - ISSN 1567-1356 - p. 381 - 392.
Department(s) Microbiological Laboratory
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) human serum-albumin - saccharomyces-cerevisiae - molecular-cloning - yarrowia-lipolytica - expression systems - beta-galactosidase - engineered yeasts - secreted proteins - gene-expression - alpha-amylase
Abstract Kluyveromyces lactis is both scientifically and biotechnologically one of the most important non-Saccharomyces yeasts. Its biotechnological significance builds on its history of safe use in the food industry and its well-known ability to produce enzymes like lactase and bovine chymosin on an industrial scale. In this article, we review the various strains, genetic techniques and molecular tools currently available for the use of K. lactis as a host for protein expression. Additionally, we present data illustrating the recent use of proteomics studies to identify cellular bottlenecks that impede heterologous protein expression.
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