Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 361618
Title Oxidative stress, and iron and antioxidant status in elderly men: differences between the Mediterranean south (Crete) and northern Europe (Zutphen)
Author(s) Buijsse, B.; Feskens, E.J.M.; Moschandreas, J.; Jansen, E.H.; Jacobs, D.R.; Kafatos, A.; Kok, F.J.; Kromhout, D.
Source European Journal of Cardiovascular Prevention and Rehabilitation 14 (2007)4. - ISSN 1741-8267 - p. 495 - 500.
Department(s) Chair Nutrition and Health over the Lifecourse
Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2007
Keyword(s) gamma-glutamyl-transferase - improves endothelial function - coronary-artery disease - cardiovascular mortality - heart-disease - risk - hypertension - genotype - adults
Abstract Background: Oxidative stress may accelerate ageing and increase the risk of chronic diseases, such as coronary heart disease (CHD). We assessed differences in oxidative stress, and iron and antioxidant status between elderly men living in Mediterranean southern Europe (Crete, Greece) and northern Europe (Zutphen, The Netherlands). Design: A cross-sectional study using data from two cohorts of the Seven Countries Study. Methods: Non-fasting blood samples were drawn in 2000 from 105 men from Crete and 139 men from Zutphen, all aged 79 years or over. All assays were performed in the same laboratory. Results: After multiple adjustments, serum levels of the markers of oxidative stress were lower in Cretan men than in men from Zutphen, as indicated by lower mean levels of hydroperoxides (33.2 versus 57.3 [mu]mol/l; P=0.005) and gamma-glutamyltransferase (20.3 versus 26.1 U/l; P=0.003). The most pronounced difference in iron status was a twofold lower mean serum ferritin level in Cretan men (69.8 [mu]g/l) compared with men from Zutphen (134.2 [mu]g/l; P
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