Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 362214
Title Biomass growth and kLa estimation using online and offline measurements
Author(s) Soons, Z.I.T.A.; Shi, J.; Pol, L.A. van der; Straten, G. van; Boxtel, A.J.B. van
Event 10th Computer Application in Biotechnology, Symposium, 2007-06-04/2007-06-06
Department(s) Systems and Control Group
Publication type Contribution in proceedings
Publication year 2007
Abstract Measurement of the key process variables is essential during biopharmaceutical production. These measurements are often not available online. This work combines frequent online measurements with infrequent offline measurements to estimate the specific growth rate, biomass, and the oxygen mass transfer coefficient during continuous and fed-batch cultivations of Bordetella pertussis online using an Extended Kalman filter, parameter adaptation, and learning.
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