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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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Record number 364316
Title Lower birth weight and attenuated adrenocortical response to ACTH in offspring from sows that orally received cortisol during gestation
Author(s) Kranendonk, G.; Hopster, H.; Fillerup, M.; Ekkel, E.D.; Mulder, E.J.H.; Wiegant, V.M.; Taverne, M.A.M.
Source Domestic Animal Endocrinology 30 (2006)3. - ISSN 0739-7240 - p. 218 - 238.
DOI https://doi.org/10.1016/j.domaniend.2005.07.001
Department(s) ID - Dier en Omgeving
Livestock Research
Chair Ethology
Human and Animal Physiology
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2006
Keyword(s) pituitary-adrenal axis - beta-hydroxysteroid dehydrogenase - prenatal stress - 11-beta-hydroxysteroid dehydrogenase - glucocorticoid exposure - adult-rats - growth restriction - fetal maturation - blood-pressure - genetic merit
Abstract Prenatal stress is known to affect several offspring characteristics, but its effects depend among other factors on the period of gestation in which it is applied. In the present study, oral administration of hydrocortisone-acetate (HCA) was used to elevate cortisol concentrations in pregnant sows to levels also observed after psychological stress. HCA was administered during three different periods of gestation (115 days in pigs): period 1: 21¿50 (P1, n = 10), period 2: 51¿80 (P2, n = 10) and period 3: 81¿110 (P3, n = 10) days after insemination. Control sows (n = 11) received vehicle from 21¿110 days after insemination. When P1-, P2- and P3-sows did not receive HCA, they also received vehicle. During gestation, weekly saliva samples were taken from the sows to determine salivary cortisol concentrations. Treatment effects on sow, litter and piglet characteristics were determined. In addition, two female piglets per litter were subjected to an ACTH-challenge test at 6 weeks of age to determine the adrenocortical response to ACTH. Pigs were slaughtered at 6 months of age and slaughter weight, back fat thickness and percentage of lean meat were analysed. During the period of treatment with HCA, salivary cortisol concentrations were increased in P1-, P2- and P3-sows compared to control sows (P <0.01). The total number of piglets born per litter did not differ among treatment groups (P > 0.30), but pooled HCA-litters had a higher percentage of live born piglets (P <0.05) and fewer mummies than control litters (P <0.05). Gestation length did not differ among treatment groups (P = 0.21), but did affect treatment effects on birth weight. Overall, HCA-piglets weighed less at birth, and remained lighter until weaning (P <0.05). The salivary cortisol concentrations after i.m. injection of ACTH (2.5 IU/kg) were lower in P1- and P3-piglets compared to control piglets. At slaughter, HCA-treatment indirectly decreased lean meat percentage and increased back fat thickness. In conclusion, elevated peripheral cortisol concentrations in pregnant sows affect both litter characteristics and piglet physiology, the latter depending on the period of gestation during which concentrations were elevated. Underlying mechanisms require further investigation.
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