Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 364335
Title GnRH tandem peptides for inducing an immunogenic response to GnRH-I without cross-reactivity to other GnRH isoforms
Author(s) Turkstra, J.A.; Schaaper, W.M.M.; Oonk, H.B.; Meloen, R.H.
Source Vaccine 23 (2005)41. - ISSN 0264-410X - p. 4915 - 4920.
Department(s) Central Institute for Animal Disease Control
Livestock Research
Publication type Refereed Article in a scientific journal
Publication year 2005
Keyword(s) gonadotropin-releasing-hormone - follicle-stimulating-hormone - active immunization - luteinizing-hormone - breast-cancer - 2nd isoform - brain - secretion - growth - form
Abstract Gonadotropin releasing hormone (GnRH) occurs in various isoforms in mammals, i.e. GnRH-I (mammalian GnRH), GnRH-II (chicken GnRH-II), GnRH-III (salmon GnRH) and two forms of lamprey GnRH. The function of the latter four molecules have only been partially investigated. Also not much is known about the physiological effects of GnRH-I immunization on the function of these GnRH isoforms. In order to avoid possible harmful side-effects due to undesired neutralization of GnRH isoforms, GnRH-I specificity of antibodies raised against a panel of alternative GnRH antigens was determined. The results show that GnRH antigens can be designed which generate antibodies that specifically bind GnRH-I, without cross-reacting with other GnRH isoforms.
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